Phase 2
Completed N=52
Improving Learning-based Treatment of Cocaine Dependence With Medication
COCAINE-RELATED DISORDERS
Source: ClinicalTrials.gov NCT01526538 ↗
Enrolled (actual)
52
Serious AEs
0.0%
Results posted
Feb 2017
Primary outcomePrimary: Urinalysis Benzoylecgonine (Cocaine Metabolite)(ng/ml) — 36.7; 32.4 ng/ml
Summary
This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Urinalysis Benzoylecgonine (Cocaine Metabolite)(ng/ml) |
36.7; 32.4 | — |
| PRIMARY Medication Side-effects |
0; 0 | — |
| SECONDARY Learning Task by Itami and Uno |
81.5; 72.9 | — |
Eligibility Criteria
Inclusion Criteria
- 18-60 years of age (> 60 due to age-related effects on cognitive functioning)
- Satisfy DSM-IV criteria for cocaine dependence (primarily crack)
- Able to complete all study measures
- Currently seeking treatment for cocaine dependence
Exclusion Criteria
- Meets DSM-IV criteria for dependence on a drug other than cocaine or nicotine (may meet abuse criteria for other drugs)
- Pregnant, breast feeding, or planning to become pregnant within 3 months
- If female, do not agree to use an effective means of birth control during the course of treatment (via phone screen)
- History of seizure disorder, severe hepatic impairment, porphyria, serious head trauma, dementia, or significant cognitive impairment
- Diagnosis of current major psychiatric disorder besides substance dependence or abuse
- Reported use of DCS in the past year
- Illiteracy, as will be determined during in-person screening
- Concurrently prescribed or using ethionamide or isoniazid (both used to treat tuberculosis)
- Positive urine result for opioids at screening interview
Data sourced from ClinicalTrials.gov (NCT01526538). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.