N/A N=36 Basic Science

EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

Brain Activity Under Sedation

Bottom Line

View on ClinicalTrials.gov: NCT01543633 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2022

Primary outcome: Primary: EEG Power in Alpha, Slow, and Delta Bands — 10; 0.55; 2.5 Power of alpha band (decibels)

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Propofol (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Massachusetts General Hospital
Primary completion: Jul 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY EEG Power in Alpha, Slow, and Delta Bands	10; 0.55; 2.5	—

Summary

The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).

Eligibility Criteria

Inclusion Criteria

Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight.
American Society of Anesthesiologists (ASA) physical status I

Exclusion Criteria

History of head trauma
Surgical aneurysm clips
Cardiac pacemaker
Prosthetic heart valve
Neurostimulator
Implanted pumps
Cochlear implants
Metal rods, plates
Screws
Intrauterine device
Hearing aid
Dentures (which might create NMR artifacts)
Metal injury to eyes

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01543633). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.