N/A
Completed N=11
The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials
Source: ClinicalTrials.gov NCT01546155 ↗Enrolled (actual)
11
Serious AEs
0.0%
Results posted
Apr 2017
Primary outcomePrimary: PET/MRI Brain Activation — 0.21 percentage BOLD signal change
Summary
Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PET/MRI Brain Activation |
0.21 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy male and female adults, 21 to 50 years of age
- No contraindications to fMRI and PET scanning
- Within 15% of ideal body mass index (BMI)
Exclusion Criteria
- Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators
- Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles
- Claustrophobia
- History of head trauma
- Instability of responses to experimental pain (See Study Procedure Section Part II)
- History of asthma
- Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent
- History of smoking
- Routine exercise in excess of one hour per day and/or three times per week
- Non-fluent English speaker
Data sourced from ClinicalTrials.gov (NCT01546155). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.