N/A
N=18
Role of Infected Blood Dendritic Cells in Heart Disease Risk
Chronic Periodontitis
Bottom Line
View on ClinicalTrials.gov: NCT01568944 ↗Enrolled (actual)
18
Serious AEs
0.0%
Results posted
May 2020
Primary outcome: Primary: Frequency of Blood Dendritic Cells From Baseline — 12; 14 % MFI
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Oral Antibiotic and Oral Rinse (Drug); Standard Treatment (Procedure)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- Augusta University
- Primary completion
- Sep 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Frequency of Blood Dendritic Cells From Baseline |
12; 14 | — |
| SECONDARY Probing Attachment Levels |
4.2; 4.6 | — |
| SECONDARY Serum Cytokine Response |
22; 32 | — |
| SECONDARY Probing Depths |
4.2; 4.7 | — |
| SECONDARY Plaque Index |
2; 3 | — |
| SECONDARY Gingival Index |
2; 3 | — |
Summary
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
Eligibility Criteria
Inclusion Criteria
- generalized moderate to severe chronic periodontitis
Exclusion Criteria
- diabetes
- antibiotics treatment within 3 months
- treatment with steroids, phenytoin, cyclosporin, coumadin
- presence of conditions requiring prophylactic antibiotics per AHA
- cancer, HIV, hepB, lupus, prediagnosed heart disease, renal disease
- smoker
Data sourced from ClinicalTrials.gov (NCT01568944). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.