N/A N=233 Prevention

Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery

Post-operative Nausea · Post-operative Vomiting · Nausea Persistent

Bottom Line

View on ClinicalTrials.gov: NCT01592708 ↗

Enrolled (actual)

233

Serious AEs

0.0%

Results posted

Aug 2014

Primary outcome: Primary: Post-operative Nausea — 24; 70 percentage of subjects with PON

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Antiemetic anesthesia protocol (Other)
Age: Pediatric, Adult, Older Adult · 15+ yrs
Sex: All
Sponsor: University of North Carolina, Chapel Hill
Primary completion: Feb 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Post-operative Nausea	24; 70	—
PRIMARY Post-operative Vomiting	11; 28	—
SECONDARY Hospital Length of Stay	26.4; 28.2	—
SECONDARY Post-discharge Nausea	72; 60	—
SECONDARY Post-discharge Vomiting	22; 29	—

Summary

The purpose of this study is to determine whether a multi-modal anesthesia and pain control protocol reduces post-operative and post-discharge nausea and vomiting (PONV and PDNV) in patients undergoing upper jaw corrective surgery.

Eligibility Criteria

Inclusion Criteria

15 years old or older
Undergoing elective orthognathic surgery involving a maxillary osteotomy

Exclusion Criteria

uncontrolled GERD or hiatal hernia
glaucoma
seizure disorder
COPD
obstructive sleep apnea
chronic kidney disease stage III or greater
known prolonged QT interval (QTc > 460) or the same found incidentally
history of severe constipation
pre-existing chronic nausea or vomiting
allergies or contraindications to protocol medications
patient insistence on inhalational induction of anesthesia.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01592708). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.