N/A
N=350
Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
Cross Infection · Pneumonia, Ventilator-associated · Catheter-related Infections · Infection Due to Indwelling Urinary Catheter · Surgical Wound Infection
Bottom Line
View on ClinicalTrials.gov: NCT01640925 ↗Enrolled (actual)
350
Serious AEs
0.3%
Results posted
May 2015
Primary outcome: Primary: Incidence of Nosocomial Infection — 15; 30 participants — p=0.049
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Chlorhexidine gluconate (Drug); Standard bathing (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Joshua Swan
- Primary completion
- May 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Incidence of Nosocomial Infection |
15; 30 | 0.049 sig |
| SECONDARY Incidence of Skin Irritation |
30; 31 | — |
| SECONDARY ICU Length of Stay in Days |
7.2; 7.0 | — |
| SECONDARY Number of Patients With In-hospital Mortality |
22; 24 | — |
Summary
This prospective, randomized, controlled trial will compare the incidence of nosocomial infections (composite of primary bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and surgical site infections) that occur in intensive care unit (ICU) patients bathed with 2% chlorhexidine solution versus patients who receive standard bathing (soap and water or non-medicated cloths).
Eligibility Criteria
Inclusion Criteria
- Admission to the surgical intensive care unit at The Methodist Hospital (Houston, TX)
- Anticipated surgical intensive care unit length of stay of 48 hours or more
Exclusion Criteria
- Pregnancy
- Age less than 18 years old
- Braden score of less than 9 upon admission to the surgical intensive care unit
- Known allergy to chlorhexidine gluconate
- Active skin irritation upon admission to the surgical intensive care unit
Data sourced from ClinicalTrials.gov (NCT01640925). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.