Phase 4 N=60 Randomized Single-blind Treatment

Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients

Moderate to Advanced Chronic Periodontitis

Bottom Line

View on ClinicalTrials.gov: NCT01647282 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2017

Primary outcome: Primary: Change in Interproximal Bone Height Loss, Probing Depth and Clinical Attachment Level Over 24 Months — 3.78; 3.87; 3.57; 3.8 mm

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: locally-applied minocycline HCl (1 mg) (Drug); scaling and root planing (Sc/RP) (Procedure)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: University of Nebraska
Primary completion: Dec 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Interproximal Bone Height Loss, Probing Depth and Clinical Attachment Level Over 24 Months	3.78; 3.87; 3.57; 3.8; 5.29; 5.48	—
SECONDARY Inflammatory Biomarkers Found in Gingival Crevicular Fluid: IL-1.	9.29; 9.95; 10.30; 10.53	—

Summary

The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis within a periodontal maintenance program.

Eligibility Criteria

Inclusion Criteria

diagnosis of moderate-severe chronic periodontitis
attending regular periodontal maintenance visits at UNMC COD
one quadrant with at least one > 5 mm interproximal pocket and 3 posterior teeth

Exclusion Criteria

systemic diseases which impact periodontal inflammation and bone turnover
drugs which significantly impact periodontal inflammation and bone turnover
surgical periodontal therapy within the last year
pregnant or breast-feeding females

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01647282). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.