Phase 4
Completed N=60
Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients
Moderate to Advanced Chronic Periodontitis
Source: ClinicalTrials.gov NCT01647282 ↗
Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Dec 2017
Primary outcomePrimary: Change in Interproximal Bone Height Loss, Probing Depth and Clinical Attachment Level Over 24 Months — 3.78; 3.87; 3.57; 3.8 mm
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis within a periodontal maintenance program.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Interproximal Bone Height Loss, Probing Depth and Clinical Attachment Level Over 24 Months |
3.78; 3.87; 3.57; 3.8; 5.29; 5.48 | — |
| SECONDARY Inflammatory Biomarkers Found in Gingival Crevicular Fluid: IL-1. |
9.29; 9.95; 10.30; 10.53 | — |
Eligibility Criteria
Inclusion Criteria
- diagnosis of moderate-severe chronic periodontitis
- attending regular periodontal maintenance visits at UNMC COD
- one quadrant with at least one > 5 mm interproximal pocket and 3 posterior teeth
Exclusion Criteria
- systemic diseases which impact periodontal inflammation and bone turnover
- drugs which significantly impact periodontal inflammation and bone turnover
- surgical periodontal therapy within the last year
- pregnant or breast-feeding females
Data sourced from ClinicalTrials.gov (NCT01647282). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.