N/A
Completed N=25
Buprenorphine Disposition and Cyclosporine
Healthy
Source: ClinicalTrials.gov NCT01648270 ↗
Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Jan 2020
Primary outcomePrimary: Buprenorphine Plasma Cmax
Summary
The determine the effect of cyclosporine on buprenorphine disposition
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Buprenorphine Plasma Cmax |
— | — |
Eligibility Criteria
Inclusion Criteria
- 18-50 yr old
- Good general health with no remarkable medical conditions
- BMI < 33
- Provide informed consent
Exclusion Criteria
- Known history of liver or kidney disease
- Use of prescription or non prescription medications, herbals or foods known to be metabolized by or affecting CYP3A
- Females who are pregnant or nursing
- Known history of drug or alcohol addiction (prior or present addiction or treatment for addiction)
- Direct physical access to and routine handling of addicting drugs in the regular course of duty (a routine exclusion from studies of drugs with addiction potential)
Data sourced from ClinicalTrials.gov (NCT01648270). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.