Phase 4
Completed N=103
Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control
Source: ClinicalTrials.gov NCT01669928 ↗Enrolled (actual)
103
Serious AEs
1.6%
Results posted
Mar 2021
Primary outcomePrimary: Changes in 24 Hour Systolic Blood Pressure — 129.65; 129.75 mm Hg
◆ Published Evidence
Established
82citations · ~10 / year
Randomized Crossover Trial of the Impact of Morning or Evening Dosing of Antihypertensive Agents on 24-Hour Ambulatory Blood Pressure.
Summary
A randomised crossover trial of anti-hypertensive medication dosing regimen in effective blood pressure control.
To investigate whether there is a difference in 24 hour blood pressure (BP) control when antihypertensive medications are taken in the morning compared with the evening.
Linked Publications
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Randomized Crossover Trial of the Impact of Morning or Evening Dosing of Antihypertensive Agents on 24-Hour Ambulatory Blood Pressure.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in 24 Hour Systolic Blood Pressure |
129.65; 129.75 | — |
| SECONDARY Mean Day-time ABPM Systolic BP |
132.24; 132.77 | — |
| SECONDARY Mean Day-time ABPM Diastolic BP |
79.27; 80.55 | — |
| SECONDARY Μean Night Time ABPM Systolic BP |
122.76; 121.08 | — |
| SECONDARY Μean Night Time ABPM Diastolic BP |
70.92; 70.57 | — |
| SECONDARY Mean Clinic - Systolic BP |
129.37; 129.81 | — |
| SECONDARY Mean Clinic - Diastolic BP |
77.26; 77.41 | — |
| SECONDARY Self Reported Side Effects |
0; 3 | — |
| SECONDARY Quality of Life Score |
84.14; 84.04 | — |
Eligibility Criteria
Inclusion Criteria
- Caucasian patients aged 18-80 years;
- History of any grade of hypertension for at least 1 year, including at least 3 months of constant antihypertensive medication (consisting of ≥ 1 antihypertensive drugs, each administered in one dose daily), with reasonably controlled BP (≤150/90 mmHg and ≥ 115/75 mmHg on usual medication) based on previous clinic records, in the last 3 months.
Exclusion Criteria
- BP levels > 150/90 mmHg or 20 mm Hg drop of systolic BP or a > 10 mm Hg drop of diastolic BP or both between 1 and 3 min after standing from the sitting position.
- Known Extreme dippers at baseline (fall of mean night time SBP > 20% of mean day time SBP)
- Individuals with jobs which require night-time shift work.
- Pregnant women or those planning to become pregnant.
Data sourced from ClinicalTrials.gov (NCT01669928) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.