Phase 3
N=1,482
Efficacy and Safety Study of SCH 900237/MK-8237 in Children and Adults With House Dust Mite-Induced Allergic Rhinitis/Rhinoconjunctivitis (P05607)
Rhinitis, Allergic, Perennial · Rhinitis, Allergic, Nonseasonal
Bottom Line
View on ClinicalTrials.gov: NCT01700192 ↗Enrolled (actual)
1,482
Serious AEs
1.2%
Results posted
Mar 2017
Primary outcome: Primary: Average Total Combined Rhinitis Score (TCRS) During Last 8 Weeks of Treatment — 4.67; 5.49 Score on a Scale — p=<0.001
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- MK-8237 tablets (Biological); Placebo tablets (Biological); Rescue Medication: Self-Injectable Epinephrine (Drug); Rescue Medication: Loratadine tablets (Drug); Rescue Medication: Olopatadine ophthalmic drops (Drug); Rescue Medication: Mometasone furoate nasal spray (Drug)
- Age
- Pediatric, Adult, Older Adult · 12+ yrs
- Sex
- All
- Sponsor
- ALK-Abelló A/S
- Primary completion
- Apr 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Average Total Combined Rhinitis Score (TCRS) During Last 8 Weeks of Treatment |
4.67; 5.49 | <0.001 sig |
| PRIMARY Number of Participants Who Experience At Least One Adverse Event (AE) |
676; 539 | — |
| PRIMARY Number of Participants Who Discontinue Study Drug Due to an AE |
73; 19 | — |
| SECONDARY Average Rhinitis Daily Symptom Score (Rhinitis DSS) During Last 8 Weeks of Treatment |
3.83; 4.46 | <0.001 sig |
| SECONDARY Average Rhinitis Daily Medication Score (Rhinitis DMS) During Last 8 Weeks of Treatment |
0.84; 1.03 | 0.154 |
| SECONDARY Average Total Combined Rhinoconjunctivitis Score (TCS) During Last 8 Weeks of Treatment |
6.40; 7.62 | <0.001 sig |
| SECONDARY Average Allergic Rhinitis/Rhinoconjunctivitis Symptoms Assessed by Visual Analogue Scale (VAS) During Last 8 Weeks of Treatment |
42.29; 47.96 | <0.001 sig |
Summary
The purpose of this study is to assess the efficacy and safety of MK-8237 (SCH 900237) in the treatment of House Dust Mite (HDM)-Induced Allergic Rhinitis/Rhinoconjunctivitis (AR/ARC) in children and adults.
The primary hypothesis of this study is that administration of MK-8237, compared to placebo, results in significant reduction in the average total combined rhinitis score (TCRS).
Eligibility Criteria
Inclusion Criteria
- History of AR/ARC to house dust of 1 year duration or more (with or without asthma)
- If female of childbearing potential, has a negative urine pregnancy test at Screening and agrees to remain abstinent or use (or have their partner use) an acceptable method of birth control within the projected duration of the study
- Able to read, understand and complete questionnaires and diaries
Exclusion Criteria
- Clinically relevant history of symptomatic ARC caused by animal dander, molds and/or cockroach (e.g. present in the home, job, daycare, etc.) or other perennial allergen
- History of symptomatic seasonal ARC and/or asthma due to an allergen to which the participant is sensitized and regularly exposed
- Nasal condition that could confound the efficacy or safety assessments (e.g., nasal polyposis)
- Received an immunosuppressive treatment within 3 months prior to screening
- Unstable or severe asthma, or has experienced a life-threatening asthma attack or an occurrence of any clinical deterioration of asthma that resulted in emergency treatment, hospitalization due to asthma, or treatment with systemic corticosteroids (but allowing short-acting beta agonists [SABAs]) at any time within 3 months prior to screening
- Asthma requiring high-dose inhaled corticosteroids (ICS) within 6 months prior to screening
- History of anaphylaxis with cardiorespiratory symptoms with prior immunotherapy, unknown cause or inhalant allergen
- History of chronic urticaria and/or angioedema within 2 years prior to screening
- History of chronic sinusitis during 2 years prior to screening
- Pregnant, breastfeeding, or expecting to conceive within the projected duration of the study
- Previous immunotherapy treatment with any HDM allergen for more than 1 month within 5 years prior to screening
- Previous exposure to MK-8237
- Receiving ongoing treatment with any specific immunotherapy at screening
- Known history of allergy, hypersensitivity or intolerance to investigational medicinal products (except for D. pteronyssinus and/or D. farinae), rescue medications or self-injectable epinephrine
- Unable to meet medication washout requirements prior to screening
- Unable or unwilling to comply with the use of self-injectable epinephrine
- Business or personal relationship with investigational site personnel or Sponsor who is directly involved with the conduct of the study
- Likely to travel for extended periods of time during the efficacy assessment period
- Participating in a different investigational study at any site during this study
Data sourced from ClinicalTrials.gov (NCT01700192). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.