Phase 2
N=36
Vacc-4x + Lenalidomide vs. Vacc-4x +Placebo in HIV-1-infected Subjects on Antiretroviral Therapy (ART)
HIV-1 Infection
Bottom Line
View on ClinicalTrials.gov: NCT01704781 ↗Enrolled (actual)
36
Serious AEs
2.8%
Results posted
Mar 2017
Primary outcome: Primary: Part A: To Establish Highest Tolerated Dose of Lenalidomide, Dose-Limiting Toxicity — 0; 0; 0 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Lenalidomide (Drug); Lenalidomide placebo (Drug); Vacc-4X (Drug); rhuGM-CSF (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Bionor Immuno AS
- Primary completion
- Aug 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Part A: To Establish Highest Tolerated Dose of Lenalidomide, Dose-Limiting Toxicity |
0; 0; 0 | — |
| PRIMARY Part A: To Establish Highest Tolerated Dose of Lenalidomide, CD4 Counts Over Time |
437.3; 436.3; 454.2; 393.0; 317.0; 342.2 | — |
| PRIMARY Part B: Change in CD4 Count |
90.9; 42.2; 106.3; 49.1 | — |
| SECONDARY Part B: Change in CD8 Count |
734.2; 655.3; 653.8; 784.5; 744.9; 794.5 | — |
| SECONDARY Part B: Evaluate the Effect on HIV Viral Load |
0.8; 2.5; 5.1; 0.0; 6.4; 0.9 | — |
| SECONDARY Part B: Incidents of Delayed-type Hypersensitivity |
0; 0; 0; 1; 5; 2 | — |
| SECONDARY Part A and B: Safety and Tolerability |
3; 2; 6; 10; 9; 0 | — |
Summary
During the course of HIV infection the number of CD4 cells decreases, resulting in a reduced immunological response and ultimately immune deficiency. Vacc-4x is a peptide-based HIV immunotherapy and the primary objective is to strengthen the immune system's response to HIV p24. By adding Lenalidomide, an immunomodulatory agent, as a supporting drug, it is anticipated that the effect of Vacc-4x might be enhanced.
Eligibility Criteria
Inclusion Criteria
- Men, age ≥ 18 and ≤ 55 years at the time of screening.
- Women, age ≥ 50 and ≤ 55 years at the time of screening, who are not of childbearing potential (see Exclusion criteria, point 9). Childbearing status must be documented.
- Clinically stable on ART for the last 18 months (changes in therapy are allowed as long as the viral load is stable).
- Well controlled with no treatment failure due to ART resistance in the past
- Screening plasma viral load (HIV-1 RNA) less than 50 copies/mL for the last six months. If screening value is between 50-500 copies/mL rescreening is allowed. Single blips (up to 500 copies/mL) are allowed.
- Screening CD4 cell count ≥ 200x10^6 cells/L and ≤500x10^6 cells/L. (Rescreening is allowed)
- Laboratory test results within these ranges: Absolute neutrophil count (ANC) >1.0x10^9 /L, Platelet count >75x10^9 /L and eGRF (MDRD) >60 mL/min
- Signed informed consent
- Willingness to adhere to Global Pregnancy Prevention Risk Management Plan Lenalidomide
Exclusion Criteria
- Reported pre-study AIDS-defining illness within the previous year
- Malignant disease.
- On chronic treatment with immunosuppressive therapy.
- Autoimmune disorders, present or in the past if there is an increased risk of disease exacerbation.
- Unacceptable values of the hematologic and clinical chemistry parameters (including those associated with hemophilia), as judged by the Investigator or the Sponsor (or designee), including creatinine values >1.5x upper limit of normal (ULN), and AST (SGOT), ALT (SGPT), and alkaline phosphatase values >2.5x ULN.
- Concurrent chronic active infection such as viral hepatitis B or C or tuberculosis.
- Previous thromboembolic events or patient is currently immobilized
- Sexually active subjects who do not adhere to Global Pregnancy Prevention Risk Management Plan Lenalidomide
- Current participation in other clinical therapeutic studies.
- Females of childbearing potential will be excluded from this trial. A female of childbearing potential (FCBP) is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e. has had menses at any time in the preceding 24 consecutive months).
- The development of erythema nodosum if characterized by a desquamating rash while previously
- Incapability of compliance to the treatment protocol, in the opinion of the Investigator.
Data sourced from ClinicalTrials.gov (NCT01704781). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.