N/A
Completed N=64
Village Interactive Training and Learning Study
Aged
Source: ClinicalTrials.gov NCT01709799 ↗
Enrolled (actual)
64
Serious AEs
1.6%
Results posted
Jun 2015
Primary outcomePrimary: Bird Safari Subtest of PositScience Insight — 50.043; 50.292; 49.570; 43.218 T-score units — p=< .001
Summary
The purpose of this research study is to help scientists and health care providers learn more about preventing dementia and brain disease in older adults. There is an urgent need to develop strategies to prevent or slow down memory loss and brain function decline in the elderly.
In this study, the investigators hope to learn how physical exercise and a brain training program work together to improve thinking and memory in older adults. Specifically, these aims include:
* Learning whether physical activities (like biking or treadmill walking or Wii Fit games) will help improve the benefits of a brain training program. Based on preliminary results and that in the literature, the investigators anticipate greater cognitive benefits in the Exercise + Cognitive training groups than the Cognitive Training alone group.
* To determine whether the benefits of adding exercise will occur quickly or develop more gradually over time. The investigators suspect that a major benefit of exercise pre-dosing will occur by the 12th week of the program.
* To examine whether Wii-Fit exercise games cause similar effects on brain training as traditional exercise programs such as biking or walking. Although several recent studies have raised questions about the true aerobic benefit of exergames such as Wii-Fit Plus, other evidence suggests that these weaker aerobic benefits may be offset by the greater novelty and interest level afforded by exergames.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Bird Safari Subtest of PositScience Insight |
50.043; 50.292; 49.570; 43.218; 43.474; 43.143 | < .001 sig |
| PRIMARY Jewel Diver Subtest of PositScience Insight |
48.940; 51.052; 50.570; 63.872; 61.577; 63.205 | <.001 sig |
| PRIMARY Master Gardener Subtest of PositScience Insight |
49.938; 50.082; 49.833; 44.600; 44.851; 44.542 | <0.001 sig |
| PRIMARY Road Tour Subtest of PositScience Insight |
50.097; 53.424; 47.427; 40.279; 37.197; 36.622 | <0.001 sig |
| PRIMARY Sweep Seeker Subtest of PositScience Insight |
51.002; 48.784; 49.505; 43.846; 44.003; 42.021 | <0.001 sig |
| SECONDARY Timed Instrumental Activities of Daily Living Task |
52.065; 49.084; 48.094; 51.040; 47.540; 46.948 | 0.630 |
Eligibility Criteria
Inclusion Criteria
- Age 60+
- Generally Healthy
- On stable does of medications
- Absence of significant behavioral or cognitive dysfunction
Exclusion Criteria
- Significant cognitive or behavioral problems or symptoms
- History of falls >2 in the past month
- Unstable medical conditions such as uncontrolled diabetes, uncontrolled cardiac disease, uncontrolled hypertension, or other that would increase risk of side effects performing physical activity
- History of substance abuse in last 6 months
- Known structural brain abnormality, previous major debilitating strokes or seizures, traumatic brain injury
- Had complete neuropsychological testing in the last 6 months
- Previous participation in cognitive or exercise training study within last 3 months
- Currently engaging in moderate to heavy exercise >125 mins. week at 75% Target Heart Rate
Data sourced from ClinicalTrials.gov (NCT01709799). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.