N/A
Completed N=63
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
Source: ClinicalTrials.gov NCT01710800 ↗Enrolled (actual)
63
Serious AEs
0.0%
Results posted
Jan 2013
Primary outcomePrimary: Number of Impedance Episodes Following PPI and Placebo — 47; 53 number of episodes
Summary
The purpose of this study is to determine the effects of proton pump inhibitors (PPIs) on the total number of reflux episodes in the distal esophagus measured by impedance in patients with and without gastroesophageal reflux disease (GERD) based on 24-hour pH testing. In addition to changing the acidity of the refluxate, the investigators hypothesize that PPIs also reduce the total number of reflux episodes due to its anti-secretory effects.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Impedance Episodes Following PPI and Placebo |
47; 53 | — |
Eligibility Criteria
Inclusion Criteria
- All adults patients (age 18 or older) with reflux symptoms willing to participate
Exclusion Criteria
- Pregnancy
- Prior esophageal or gastric surgery
- Achalasia
- Scleroderma
- Gastroparesis.
Data sourced from ClinicalTrials.gov (NCT01710800). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.