Phase 4
Completed N=122
Dexamethasone for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Cesarean Sections
Source: ClinicalTrials.gov NCT01734161 ↗Enrolled (actual)
122
Serious AEs
0.0%
Results posted
Apr 2017
Primary outcomePrimary: Incidence of Post-operative Nausea and/or Vomiting — 29; 24 Participants
◆ Published Evidence
Emerging
13citations · ~2 / year
The effect of intravenous dexamethasone on postoperative nausea and vomiting after Cesarean delivery with intrathecal morphine: a randomized-controlled trial.
Summary
Patients who present for scheduled (non-emergent) cesarean section will be given either intravenous dexamethasone or placebo prior to receiving a duramorph containing spinal anesthetic. The investigators will then compare the incidence of nausea and vomiting and the use of rescue anti-nausea medications in both groups. Our hypothesis is that patients receiving dexamethasone prior to duramorph containing spinal anesthesia for cesarean section will have a significantly lower incidence and severity of PONV at 0, 1, 3, 6, and 24 hours following surgery.
Linked Publications
-
The effect of intravenous dexamethasone on postoperative nausea and vomiting after Cesarean delivery with intrathecal morphine: a randomized-controlled trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Incidence of Post-operative Nausea and/or Vomiting |
29; 24 | — |
Eligibility Criteria
Inclusion Criteria
- Women aged 18-46 presenting for scheduled primary or repeat cesarean sections and have consented to study
Exclusion Criteria
- allergy to dexamethasone or morphine
- history of gastrointestinal disease
- history of severe nausea during pregnancy (hyperemesis gravidarum)
- use of anti-emetic in the past 24 hours
- history of gestational diabetes or diabetes mellitus
- history of hypertension prior to or during pregnancy
- presence of non-viable fetus
Data sourced from ClinicalTrials.gov (NCT01734161) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.