N/A
N=1,377
The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'
HIV Positive · Ageing
Bottom Line
View on ClinicalTrials.gov: NCT01737047 ↗Enrolled (actual)
1,377
Serious AEs
0.0%
Results posted
Sep 2025
Primary outcome: Primary: The Prevalence of Reported Aches and Pains in the Last Month Across the 3 Age Groups — 473; 224; 188 participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Imperial College London
- Primary completion
- Jan 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Prevalence of Reported Aches and Pains in the Last Month Across the 3 Age Groups |
473; 224; 188 | — |
Summary
The purpose of this study is to identify medical conditions that may cause particular problems to individuals receiving care for HIV infection over the age of 50. In addition, as the effects and potentially the side effects, of HIV medication may change with age, this study will also investigate the association between age and differing effects of antiretroviral therapies such as treatment outcomes, side effects and the levels of drugs in blood.
Results from this study may inform future HIV treatment guidelines on how individuals with HIV infection are monitored. The results may also assist in the design of future studies for the treatment of diseases associated with ageing.
Eligibility Criteria
Inclusion Criteria
Older HIV-positive cohort (n=1000):
- documented HIV infection
- age >50 years at study entry
- self defined white or black African ethnicity
- likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African
- able to comprehend study patient information leaflet
-Younger HIV-positive cohort (n=500):
- documented HIV infection
- age 50 years at study entry
- self defined white or black African ethnicity
- registered with a General Practitioner and gives permission for contact with that General Practitioner.
Exclusion Criteria
- in the opinion of the investigator, those unable or unwilling to comply with the requirements of the study
- life expectancy less than 6 months
Data sourced from ClinicalTrials.gov (NCT01737047). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.