N/A
N=268
A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus
Cesarean Section
Bottom Line
View on ClinicalTrials.gov: NCT01741259 ↗Enrolled (actual)
268
Serious AEs
0.0%
Results posted
Oct 2017
Primary outcome: Primary: Verbal Pain Score With Movement — 1.92; 1.50 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Meperidine (Drug)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Mercy Research
- Primary completion
- Apr 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Verbal Pain Score With Movement |
1.92; 1.50 | — |
| SECONDARY Nausea and Vomiting |
1; 3 | — |
| SECONDARY Pruritus |
20; 10 | — |
| SECONDARY Dysphoria |
0; 0 | — |
| SECONDARY Inadequate Analgesia |
7; 3 | — |
| SECONDARY Adverse Outcomes |
0; 0 | — |
| SECONDARY Total Drug Dose |
5.42; 8.49 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #1 |
1.89; 1.45 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #2 |
5.79; 5.10 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #3 |
14.47; 11.78 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #4a |
4.04; 3.13 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #4b |
4.02; 3.71 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #4c |
2.016; 1.487 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #4d |
2.04; 1.68 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #5a |
1.311; 1.504 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #5b |
.47; .34 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #5c |
.85; .79 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #5d |
1.42; 1.49 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #6a |
.49; .69 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #6b |
2.26; 2.91 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #6c |
2.661; 2.419 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #6d |
.84; 1.13 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #7 |
77.05; 81.82 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #8 |
8.996; 9.258 | — |
| SECONDARY American Pain Society Patient Outcome Questionnaire #9 |
8.76; 9.41 | — |
Summary
The purpose of this study is to determine if epidural meperidine administered by patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled bolus.
Eligibility Criteria
Inclusion Criteria are as follows:
- Over the age of 18
- Undergoing non-urgent, non-emergent cesarean section at Mercy Hospital St. Louis
Exclusion Criteria
- non-English speaking
- mentally disabled
- allergy to meperidine
- seizure disorder
- renal impairment defined as a serum creatinine >0.8 mg/dL or patients who give a history of renal impairment
- fever greater than 101
- patients receiving low molecular weight heparin at any dose or unfractionated heparin at doses greater than 5000 u subcutaneous twice daily
- pre-eclampsia requiring magnesium due to post-partum room assignment
- obstructive sleep apnea due to post-partum room assignment
- post-partum hemorrhage due to post-partum room assignment
Data sourced from ClinicalTrials.gov (NCT01741259). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.