Phase 2
N=261
Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial
Aneurysm
Bottom Line
View on ClinicalTrials.gov: NCT01756833 ↗Enrolled (actual)
261
Serious AEs
55.5%
Results posted
Nov 2021
Primary outcome: Primary: Difference in Z-score for Rank of Maximum Transverse Diameter (MTD) Regressed on Z-score at Baseline to Assess Growth in Abdominal Aortic Aneurysm MTD Determined by CT Scans at Two-year Follow-up and Baseline (Pre-randomization). — 0.0262; -0.0258 z-score — p=0.71
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Doxycycline (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 55+ yrs
- Sex
- All
- Sponsor
- University of Maryland, Baltimore
- Primary completion
- Jul 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Difference in Z-score for Rank of Maximum Transverse Diameter (MTD) Regressed on Z-score at Baseline to Assess Growth in Abdominal Aortic Aneurysm MTD Determined by CT Scans at Two-year Follow-up and Baseline (Pre-randomization). |
0.0262; -0.0258 | 0.71 |
| SECONDARY Maximum Transverse Diameter, cm |
4.40; 4.40; 4.49; 4.48; 4.61; 4.61 | — |
| SECONDARY Volume, cm^3 |
102.90; 100.40; 106.00; 105.00; 113.60; 111.20 | — |
| SECONDARY MMP-9, ng/ml |
60.9; 61.9; 63.0; 61.0; 48.8; 68.3 | — |
| SECONDARY CRP, mg/l |
5.4; 4.5; 3.5; 4.1; 3.5; 5.7 | — |
Summary
The primary aim of this study is to determine if doxycycline (100 mg bid) will inhibit (by at least 40%) the increase in greatest transverse diameter of small abdominal aortic aneurysms (3.5-5.0 cm in men, 3.5-4.5 cm in women) over a 24-month period of observation in comparison to a placebo-treated control group.
Eligibility Criteria
Inclusion Criteria
- Patients 55 years of age or older, women post-surgical menopause or at least two years since last menses if natural menopause.
- CT scan documented infrarenal abdominal aortic aneurysm with maximum transverse diameter larger than 35 mm and no greater than 50 mm, in men, and larger than 35 mm and no greater than 45 mm in women.
Exclusion Criteria
- Patients will be excluded from the study if they are unable to give their own informed consent to participate.
- have symptoms related to abdominal aortic aneurysm.
- have other intra-abdominal vascular pathology that may require repair within 24 months (e.g., renal artery stenosis, large iliac artery aneurysms, iliac occlusive disease, aneurysmal involvement of the renal artery).
- have had previous abdominal aortic aneurysm repair by open surgical or endovascular technique.
- have an active malignancy with life expectancy less than two years.
- have an allergy to tetracycline.
- are currently or have been recently treated (previous six months) with tetracycline derivatives.
- they are currently taking anti-seizure medicines metabolized by pathways influenced by doxycycline (e.g., carbamazepine, phenytoin, and barbiturates).
- stage II hypertension (patients whose blood pressure is persistently in the range of systolic > 160 mm Hg or diastolic > 100 mm Hg despite primary physician's best effort to achieve adequate therapy.
- have dialysis dependent renal failure or impending dialysis treatment for renal insufficiency.
- have a chronic infection requiring long-term (> 2 weeks) antibiotics.
- have known genetic syndromes responsible for the abdominal aortic aneurysm (e.g., Marfan's Syndrome).
- are under treatment with systemic immunosuppressive agents.
- could become pregnant.
- are not good candidates for clinical trial participation.
- are enrolled in another clinical trial.
Data sourced from ClinicalTrials.gov (NCT01756833). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.