N/A
N=60
Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models
Healthy
Bottom Line
View on ClinicalTrials.gov: NCT01759160 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Mar 2013
Primary outcome: Primary: SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes. — -31.1; -31.7 ml/beat/m^2
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Marsh Plasma TCI with high initial target (Procedure); Schnider Plasma TCI with high initial target (Procedure)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Primary completion
- Jan 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes. |
-31.1; -31.7 | — |
| SECONDARY NI (Narcotrend Index) Reduction |
— | — |
| SECONDARY CVP (Central Venous Pressure) |
— | — |
Summary
To compare the hemodynamic changes during anesthesia induction between Marsh and Schnider plasma TCI models. We put forward a hypothesis that, if one TCI model is associated with much more prominent vasodilation effect or cardiac depression, a more sharp decrease in mean arterial pressure, systemic vascular resistance , central venous return or stroke volume would be observed.
Eligibility Criteria
Inclusion Criteria
- Patients between the ages of 18 years and 70 years
- ASA physical status I and II
- surgical procedures requiring general anesthesia with continuous CVP and arterial pressure monitoring.
Exclusion Criteria
- Patients younger than 16 y or older than 65 y
- Body Mass Index (BMI) 30
- emergency surgery
- allergy to any of the drugs used
- inability to communicate effectively
- severe cardiovascular dysfunction
- patient refusal and patients on long-term opioids or sedative medication.
Data sourced from ClinicalTrials.gov (NCT01759160). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.