N/A Completed N=60 Randomized Single-blind Diagnostic

Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models

Healthy

Source: ClinicalTrials.gov NCT01759160 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2013

Primary outcomePrimary: SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes. — -31.1; -31.7 ml/beat/m^2

Summary

To compare the hemodynamic changes during anesthesia induction between Marsh and Schnider plasma TCI models. We put forward a hypothesis that, if one TCI model is associated with much more prominent vasodilation effect or cardiac depression, a more sharp decrease in mean arterial pressure, systemic vascular resistance , central venous return or stroke volume would be observed.

Outcome Measures

Outcome	Result	p-value
PRIMARY SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes.	-31.1; -31.7	—
SECONDARY NI (Narcotrend Index) Reduction	—	—
SECONDARY CVP (Central Venous Pressure)	—	—

Eligibility Criteria

Inclusion Criteria

Patients between the ages of 18 years and 70 years
ASA physical status I and II
surgical procedures requiring general anesthesia with continuous CVP and arterial pressure monitoring.

Exclusion Criteria

Patients younger than 16 y or older than 65 y
Body Mass Index (BMI) 30
emergency surgery
allergy to any of the drugs used
inability to communicate effectively
severe cardiovascular dysfunction
patient refusal and patients on long-term opioids or sedative medication.

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Data sourced from ClinicalTrials.gov (NCT01759160). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.