N/A
N=12
Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
Inflammation
Bottom Line
View on ClinicalTrials.gov: NCT01780922 ↗Enrolled (actual)
12
Serious AEs
—
Results posted
Jul 2014
Primary outcome: Primary: Reduced Glutathione (GSH) Concentrations in Red Blood Cells — 1.38; 1.22; 1.23; 1.12 mmol/L
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Low Calorie Cranberry Juice Cocktail (Other); Cranberry Extract Beverage (Other); Non-Cranberry Beverage (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Washington State University
- Primary completion
- Oct 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Reduced Glutathione (GSH) Concentrations in Red Blood Cells |
1.38; 1.22; 1.23; 1.12; 1.24; 1.26 | — |
| PRIMARY Superoxide Dismutase (SOD) Activity in Red Blood Cells |
19.0; 17.6; 20.3; 19.6; 17.1; 20.7 | — |
| PRIMARY Glutathione Peroxidase (GPx) Activity in Red Blood Cells |
174; 161; 163; 169; 185; 149 | — |
| PRIMARY Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG) |
30.7; 33.6; 29.2; 36.5; 31.0; 34.6 | — |
| PRIMARY C-Reactive Protein (CRP) Concentrations in Plamsa |
1.10; 1.18; 0.87; 0.85; 1.03; 0.99 | — |
| PRIMARY Nitric Oxide (NO) Concentrations in Plamsa |
14.9; 16.6; 13.1; 13.0; 15.3; 12.2 | — |
| PRIMARY Interleukin-1alpha (IL-1a) Concentrations in Plasma |
17; 21; 68; 49; 54; 61 | — |
| PRIMARY Interleukin-1beta (IL-1b) Concentrations in Plasma |
22; 25; 39; 35; 31; 33 | — |
| PRIMARY Interleukin-2 (IL-2) Concentrations in Plasma |
0; 1; 13; 7; 9; 6 | — |
| PRIMARY Interleukin-4 (IL-4) Concentrations in Plasma |
15; 21; 27; 19; 24; 28 | — |
| PRIMARY Interleukin-6 (IL-6) Concentrations in Plasma |
34; 61; 74; 50; 80; 56 | — |
| PRIMARY Interleukin-8 (IL-8) Concentrations in Plasma |
7; 12; 19; 11; 12; 24 | — |
| PRIMARY Interleukin-10 (IL-10) Concentrations in Plasma |
21; 18; 19; 15; 14; 14 | — |
| PRIMARY Interferon-gamma (IFN-y) Concentrations in Plasma |
13; 20; 16; 11; 17; 16 | — |
| PRIMARY Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma |
23; 34; 30; 24; 21; 31 | — |
| PRIMARY Urinary Anti-bacteria Adhesion Activity |
0.39; 0.45; 0.30; 2.34; 2.54; 1.62 | — |
Summary
The purpose of this study is to determine the effects of a single dose of cranberry beverage in healthy adults on the kinetic uptake of polyphenol compounds and polyphenol metabolites, and antioxidative and anti-inflammatory activity.
Eligibility Criteria
Inclusion Criteria
- Men & women; aged 18-35 years
- BMI: 19-25 kg/m2
Exclusion Criteria
- Any significant chronic disease, hypertension, ulcers, dyspepsia, lactose intolerance, allergy, psychotic illness
- Had major gastrointestinal surgery or on prescription or surgical treatment
- Any condition that may interfere with the digestion, absorption, metabolism or excretion of nutrients
- Regularly smoked in the previous 6 months
- On medication or ingested a prescribed drug at any time within the 14 days preceding study enrolment (excluding hormonal contraceptives and hormone replacement therapy) or over-the-counter preparation within 7 days preceding enrolment
- Risk factors for AIDS or known HIV positive status
- Pregnant or lactating
- High intake of chocolate or similar high polyphenol foods
- Regular intake of vitamin and polyphenol supplements
- Drug and alcohol misuse
- Currently participating or had participated in another clinical study during the previous 3 weeks
- Donated blood in the previous 3 weeks
- Exercise more than 3 times/week for longer than 45 min each time
Data sourced from ClinicalTrials.gov (NCT01780922). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.