N/A
Completed N=30
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease
Parkinson's Disease With Dementia
Source: ClinicalTrials.gov NCT01785628 ↗
Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Aug 2013
Primary outcomePrimary: Change in Unified Parkinson's Disease Rating Scale (UPDRS) From Baseline to 8 Weeks. — 71.6; 66.7; 67.9; 65.2 Scores on a scale
Summary
The project will investigate the effect of pharmacological and electric modulation of N-methyl-D-aspartate (NMDA) pathway on the cognitive flexibility and volitional movement preparation in patients with Parkinson's disease (PD).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Unified Parkinson's Disease Rating Scale (UPDRS) From Baseline to 8 Weeks. |
71.6; 66.7; 67.9; 65.2; 69.3; 67.6 | — |
| SECONDARY Change in Cognitive Abilities Screening Instrument (CASI) From Baseline to 8 Weeks. |
50.9; 63.9; 53.1; 63.9; 52.4; 63.9 | — |
| SECONDARY Change in Clinical Dementia Rating (CDR) From Baseline to 8 Weeks. |
2.3; 1.1; 2.1; 1.1; 2.0; 1.1 | — |
| SECONDARY Change in Neuropsychiatry Inventory (NPI) From Baseline to 8 Weeks. |
18.4; 14.9; 14.8; 14.1; 12.4; 11.7 | — |
| SECONDARY Change in Behavioral Pathology in Alzheimer's Disease Rating Scale (Behave-AD) From Baseline to 8 Weeks. |
10.0; 7.9; 8.4; 5.2; 7.5; 6.8 | — |
| SECONDARY Change in Hamilton Depression Rating Scale (HAM-D) From Baseline to 8 Weeks. |
11.8; 7.6; 9.9; 7.6; 10.1; 7.8 | — |
| SECONDARY Change in Beck Depression Inventory-II (BDI-II) From Baseline to 8 Weeks. |
14.3; 9.9; 15.6; 10.5; 15.8; 10.2 | — |
| SECONDARY Change in The 39-item Parkinson's Disease Questionnaire (PDQ-39) From Baseline to 8 Weeks. |
68.0; 64.8; 67.9; 60.9; 65.9; 60.9 | — |
Eligibility Criteria
Inclusion Criteria
- The diagnosis of PD-D will be based on the criteria proposed by 2007 movement disorders PD-D task force. (Emre M et.al. Mov Disord 2007; 22:1689-1707)
Exclusion Criteria
- Acute confusion due to systemic illnesses or drug intoxication.
- Major depression
- Features compatible with "Probable Vascular dementia.
- Patient who is pregnant.
Data sourced from ClinicalTrials.gov (NCT01785628). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.