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N/A N=65 Randomized Treatment

Contingency Management Treatment for Crack Addiction - Study With Brazilian Population

Cocaine Related Disorders

Enrolled (actual)
65
Serious AEs
0.0%
Results posted
Jun 2017
Primary outcome: Primary: Longest Duaration of Achieved Abstinance — 0; 7; 1; 8 number of participants

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
ST+CM (Behavioral); standard treatment (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Federal University of São Paulo
Primary completion
Jun 2015

Outcome Measures

OutcomeResultp-value
PRIMARY
Longest Duaration of Achieved Abstinance
0; 7; 1; 8; 1; 12
PRIMARY
Percentage Samples Submitted Negative for Crack Cocaine Use
8.3; 46.5
PRIMARY
Number of Participants Completing 4, 8 and 12 Weeks of Treatment
0; 17; 8; 21; 11; 22
PRIMARY
Treatment Attendance
3.7; 19.5
SECONDARY
Percentage Samples Submitted Negative for Alcohol Use
9.4; 53.9
SECONDARY
Percentage Samples Submitted Negative for Marihuana Use
9.8; 50.3

Summary

Crack addiction has become a severe health problem in Brazil. Today, crack addiction is the primary cause for inpatient treatment for all illicit substances. When compared to cocaine, crack users develop much faster diagnoses for crack dependence, shows a more compulsive pattern of use, has higher probability of living or have lived in the streets, and of engaging in illegal activities. Consequently to this, mortality of crack addicts is 7 times higher than for the rest of the population. Despite all efforts being made for the development of effective pharmacological treatments for stimulant addiction (crack included), up to today, there is no robust evidence of efficacy of any pharmacological treatment. For that reason, the use of evidence based psychosocial interventions is so important for treating this population. Although today open treatment facilities in Brazil are more and more starting to use evidence-based interventions such as motivational interviewing, cognitive behavior therapy, relapse prevention and coping skills, such treatments present very modest results when treating crack addiction. The biggest difficulties encountered when treating this population are maintaining patients in treatment, reducing crack use and achieving continued abstinence. A psychosocial treatment based in behavioral principals' named Contingency Management (CM) is widely applied in the USA. Recent meta-analyses and review studies present robust evidence that, when applied alone or in adjunction with other psychosocial and pharmacological treatment, CM is the most effective treatment for what regards, treatment retention, reducing drug use and promoting continued abstinence. The purpose of this study is to evaluate if Contingence Management (CM) can be affective in the treatment of crack addiction in Brazil. To accomplish this, 60 individuals (male and female from 18 to 65 years of age) seeking open treatment for crack addiction will be randomized to 2 treatment conditions (Standard treatment (ST) or ST+CM. Both treatments will last 12 weeks with 3 and 6-month follow-up. In both groups patients will be encourage to leave urine samples 3 times week. Hypotheses: Patients receiving ST+CM will stay longer in treatment, have more negative tests for cocaine/crack, and achieve longer periods of cocaine/crack abstinence when compared to patients receiving ST alone.

Eligibility Criteria

Inclusion Criteria

  • Current diagnose of crack addiction (DSM IV)
  • having used crack in the last month

Exclusion Criteria

  • Current psychotic disorder
  • Diagnose of schizophrenia
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01815645). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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