N/A
Completed N=40
Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly
Acromegaly
Source: ClinicalTrials.gov NCT01819883 ↗
Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Jun 2018
Primary outcomePrimary: Change in Liver Fat — 0.03 Lipid/water ratio
Summary
This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Liver Fat |
0.03 | — |
| PRIMARY Change in Thigh Muscle Cross-sectional Area |
154 | — |
Eligibility Criteria
Inclusion Criteria
- Ages 18 - 75 yr (both groups)
- Study subjects with active acromegaly
- Healthy controls
Exclusion Criteria
- Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer.
- Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus.
- Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers.
- Pregnant women
Data sourced from ClinicalTrials.gov (NCT01819883). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.