Phase 4
N=143
Ketamine Versus Etomidate for Rapid Sequence Intubation
Airway Control · Anesthesia · Intubation · Complication
Bottom Line
View on ClinicalTrials.gov: NCT01823328 ↗Enrolled (actual)
143
Serious AEs
0.8%
Results posted
May 2019
Primary outcome: Primary: SOFA Score — 6.5; 7 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Ketamine (Drug); Etomidate (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Hennepin Healthcare Research Institute
- Primary completion
- Oct 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY SOFA Score |
6.5; 7 | — |
| SECONDARY Mortality in Sepsis and Septic Shock |
1; 4 | — |
| SECONDARY Number of Patients With First-pass Success |
59; 60 | — |
| SECONDARY Doses of Post-intubation Sedation |
1; 1 | — |
| SECONDARY Number of Patients With Post-intubation Hypoxemia |
8; 13; 1; 5 | — |
| SECONDARY Number of Patients With Hypotension |
24; 30; 16; 17 | — |
| SECONDARY Peak and Plateau Pressure |
25; 26; 16; 17 | — |
| SECONDARY Mortality |
8; 15 | — |
Summary
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
Eligibility Criteria
Inclusion Criteria
- 18 years of age
- Undergoing rapid sequence intubation (RSI) in the Emergency Department
Exclusion Criteria
- Known contraindication to ketamine or etomidate
- Patient has a condition in which an increase in heart rate or blood pressure would be hazardous, as judged by the treating physician
- Patient is known or suspected of having increased intracranial pressure, based on the history and physical examination performed by the treating physician.
- Females of child-bearing age, defined as 18-50 years, who do not have a documented pregnancy test in this institution confirming that they are not pregnant or who do not have a confirmed surgical procedure preventing pregnancy, i.e., tubal ligation, hysterectomy. The timing of the pregnancy test at which the investigative team will consider a subject to be non-pregnant is a documented negative test during current hospitalization or upon direct transfer from outside institution during current illness.
- Patient declines participation in the trial by wearing a bracelet marked "KvE declined"
- Prisoner
Data sourced from ClinicalTrials.gov (NCT01823328). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.