Phase 3
N=10
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m
Alkalosis
Bottom Line
View on ClinicalTrials.gov: NCT01835912 ↗Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Jul 2014
Primary outcome: Primary: Time — 144.2; 145.3; 145.3; 144.8 seconds
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- Sodium Citrate Dihydrate (Other)
- Age
- Pediatric · 13+ yrs
- Sex
- Male
- Sponsor
- Brock University
- Primary completion
- Mar 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time |
144.2; 145.3; 145.3; 144.8 | — |
| SECONDARY Lactate |
8.8; 10.4; 9.5; 10.8 | — |
Summary
Ingestion of sodium citrate (Na-Cit), an alkalizing agent, increases extracellular pH via liver oxidation by decreasing [H+] and increasing bicarbonate concentration (HCO3-). Studies have confirmed that increasing extracellular pH promotes the efflux of La- and H+ from active muscles. This is due to an increase in activity of the pH sensitive monocarboxylate transporter as the gradient of intracellular versus extracellular H+ increases. Therefore, artificially inducing alkalosis prior to anaerobic exercise may reduce intracellular acidosis and increase the time to fatigue - defined as a decrease in force production with an increased perception of effort. The investigators will test the null hypothesis that sodium citrate ingestion (chronic and acute) will not have an effect on exercise performance compared to placebo.
Eligibility Criteria
Inclusion Criteria
- Age 13-17
- Male
- Regional, provincial and national level swimmers
Exclusion Criteria
- Females
- Level of swimming below regional level standards
- Caffeine before trials
- Chronic health concerns
- Health problems before or during the course of the trial
Data sourced from ClinicalTrials.gov (NCT01835912). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.