N/A
N=333,664
Anticoagulant Utilization Pattern
Atrial Fibrillation
Bottom Line
View on ClinicalTrials.gov: NCT01847560 ↗Enrolled (actual)
333,664
Serious AEs
—
Results posted
Jun 2019
Primary outcome: Primary: Description of the Characteristics of Anticoagulant Initiators — 3.41; 4.30; 3.59; 3.82 Scores on a scale
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Boehringer Ingelheim
- Primary completion
- Nov 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Description of the Characteristics of Anticoagulant Initiators |
3.41; 4.30; 3.59; 3.82; 2.92; 3.62 | — |
| PRIMARY Percentage of Patients Initiating Specific Anticoagulant |
15.7; NA; NA; NA; 5.4; 2.1 | — |
| PRIMARY Percentage of Patients Initiating Specific Anticoagulant Dose - Dabigatran |
90.7; 90.7; 9.3; 9.3 | — |
| PRIMARY Percentage of Patients Initiating Specific Anticoagulant Dose - Apixaban |
82.4; 84.4; 17.6; 15.6 | — |
| PRIMARY Percentage of Patients Initiating Specific Anticoagulant Dose - Rivaroxaban |
74.0; 76.4; 18.4; 16.7; 7.6; 7.0 | — |
| SECONDARY Treatment Persistence Over Time |
52.19; 52.86; 53.17; 51.58; 51.84; 48.29 | — |
Summary
This study plans to describe utilization patterns for oral anticoagulants over time in patients with non-valvular atrial fibrillation at risk for stroke using electronic claims data from a United States commercial insurance database.
Eligibility Criteria
Inclusion criteria
- A recorded diagnosis of atrial fibrillation
- Initiation of oral anticoagulant medication
- Congestive Heart Failure, Hypertension, Age > 75, Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack, Vascular Disease, Age 65-74, Sex Category (CHA2DS2-VASc) Score >=1
- At least 18 years of age on the date of anticoagulant initiation
Exclusion criteria
- Patients with missing or ambiguous age or sex information
- Patients with documented evidence of valvular disease
- Patients with less than 12 months enrolment in the UnitedHealth Research Database preceding the first dispensing
- Patients with prior use of any oral anticoagulant
Data sourced from ClinicalTrials.gov (NCT01847560). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.