N/A
N=118
Endometrial Injury and Single Embryo Transfer
Primary Infertility
Bottom Line
View on ClinicalTrials.gov: NCT01851876 ↗Enrolled (actual)
118
Serious AEs
—
Results posted
Jul 2013
Primary outcome: Primary: Clinical Pregnancy Rate
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Endometrial injury (Device)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Karadeniz Technical University
- Primary completion
- Apr 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Clinical Pregnancy Rate |
27; 18 | 0.025 sig |
| PRIMARY Clinical Pregnancy Rate |
27; 18 | 0.025 sig |
Summary
Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.
Eligibility Criteria
Inclusion Criteria
- woman age under 35 years
- history of primary infertility
- normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
- having grade I or II embryos for transfer
- agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.
Exclusion Criteria
- endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
- using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
- patients who did not proceed to follicle retrieval
- severe male infertility requiring TESA/TESA
- mullerian tract anomalies
- a history of endometrial instrumentation or surgery within a month of the study
- not agree to undergo endometrial biopsy during the COH cycle.
Data sourced from ClinicalTrials.gov (NCT01851876). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.