N/A Completed N=118 Treatment

Endometrial Injury and Single Embryo Transfer

Primary Infertility

Source: ClinicalTrials.gov NCT01851876 ↗

Enrolled (actual)

118

Serious AEs

—

Results posted

Jul 2013

Primary outcomePrimary: Clinical Pregnancy Rate

Summary

Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.

Outcome Measures

Outcome	Result	p-value
PRIMARY Clinical Pregnancy Rate	27; 18	0.025 sig

Eligibility Criteria

Inclusion Criteria

woman age under 35 years
history of primary infertility
normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
having grade I or II embryos for transfer
agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.

Exclusion Criteria

endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
patients who did not proceed to follicle retrieval
severe male infertility requiring TESA/TESA
mullerian tract anomalies
a history of endometrial instrumentation or surgery within a month of the study
not agree to undergo endometrial biopsy during the COH cycle.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01851876). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.