N/A Completed N=27 Randomized Single-blind Treatment

Muscle Weakness and Post-traumatic Knee OA

Meniscectomy

Source: ClinicalTrials.gov NCT01879852 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2014

Primary outcomePrimary: Change in International Knee Documentation Committee (IKDC) Subjective Knee Form Score — 22.2; 20.6 units on a scale

Summary

This is a single-center, randomized, single-blind (evaluator) study. Enrolled patients had a traumatic meniscal tear and underwent meniscectomy. The study included 6 weeks (12 visits) of standard or quadriceps intensive rehabilitation. The objective of the study was to determine the effect of quadriceps intensive rehabilitation on knee function and articular cartilage.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in International Knee Documentation Committee (IKDC) Subjective Knee Form Score	22.2; 20.6	—
PRIMARY Change in Tibial Articular Cartilage Volume	0.18; -1.24	—
SECONDARY Single Leg Forward Hop Index	87.1; 90.1	—
SECONDARY Change in Urinary Concentrations of C-terminal Crosslinking Telopeptide of Type II Collagen (CTX-II)	0.01; -0.11	—

Eligibility Criteria

Inclusion Criteria

traumatic onset meniscal tear (i.e. specific mechanism of injury)
meniscectomy surgery performed within 12 months of index injury
meniscal tear confirmed at the time of surgery
subject anticipates living in close proximity to Gainesville for one year following surgery.

Exclusion Criteria

bilateral injury
concomitant ligamentous injury
previous knee injury
articular cartilage defect > Grade II on Outerbridge scale
patellofemoral joint pain > 3/10 with activity
lower limb alignment > 5 degrees of valgus or varus
contraindication to an MR examination including: a pacemaker, metal implants which are not MR compatible, pregnancy and severe claustrophobia.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01879852). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.