Early Phase 1
Completed N=9
Impact of a Non-Drug Choice on Cocaine Reinforcement
Cocaine Dependence
Source: ClinicalTrials.gov NCT01906346 ↗
Enrolled (actual)
9
Serious AEs
0.0%
Results posted
May 2019
Primary outcomePrimary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 2.75; 1.38; 1.38; 4.75 cocaine choices
Summary
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate self-administration procedures and a non-drug alternative reinforcer, which is hypothesized to reduce the reinforcing effects of cocaine.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative |
2.75; 1.38; 1.38; 4.75; 5.88; 4.00 | — |
Eligibility Criteria
Inclusion Criteria
- Cocaine dependence, otherwise healthy
Exclusion Criteria
- Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
Data sourced from ClinicalTrials.gov (NCT01906346). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.