N/A N=300 Randomized Quadruple-blind Prevention

Postoperative Vomiting in Children - Is Dextrose an Effective Prophylactic Anti-emetic?

Postoperative Vomiting

Bottom Line

View on ClinicalTrials.gov: NCT01912807 ↗

Enrolled (actual)

300

Serious AEs

0.0%

Results posted

Oct 2021

Primary outcome: Primary: Number of Participants With Postoperative Vomiting Between 0 to 2 Hours — 11; 5 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Dextrose (D5NS) (Drug); Ondansetron (Control) (Drug)
Age: Pediatric · 3+ yrs
Sex: All
Sponsor: University of Saskatchewan
Primary completion: Sep 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Postoperative Vomiting Between 0 to 2 Hours	11; 5	—
SECONDARY Number of Participants Receiving Rescue Antiemetic Medications	15; 9	—

Summary

The aim of this study was to investigate the efficacy of intraoperative intravenous dextrose in preventing POV in pediatric population undergoing dental day surgery. Post-operative vomiting (POV) in children is a frequent complication. Studies using intravenous (IV) fluids containing dextrose in the perioperative period have shown improvement of POV in adults. Similar studies have not been done in children. Knowing that Intravenous (IV) fluids containing dextrose are safe and commonly used in the paediatric population, this intervention could potentially reduce the amount of rescue antiemetic medications and improve recovery in same-day surgery paediatric patients.

Eligibility Criteria

Inclusion Criteria

3 to 9 Years of age
Male and Female
ASA I and II
Paediatric patients undergoing same-day dental procedures at the Prairieview Surgical Centre.

Exclusion Criteria

Age 9
Underlying pro-emetic disease
Positive history of POV in the patient, parent or sibling
Currently on antiemetic medications
Parent refusal to sign consent
History of juvenile diabetes

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01912807). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.