Response Adapted Therapy With Bortezomib/Dexamethasone Followed by Addition of Lenalidomide in Non Responders as Initial Treatment for Patients With Multiple Myeloma

Inclusion Criteria

• Age 18 or greater at the time of signing the informed consent document.
• Patients diagnosed with symptomatic multiple myeloma based on IMWG Diagnostic Criteria. According to these criteria, patient must have
• Monoclonal plasma cells in the bone marrow ≥ 10% and/or presence of a biopsy-proven bony or extramedullary plasmacytoma and any one or more of the following myeloma defining events:
• Clonal bone marrow plasma cell percentage ≥ 60% (Note: clonality should be established by showing kappa/lambda-light-chain restriction on flow cytometry, immunohistochemistry, or immunofluorescence. Bone marrow plasma cell percentage should preferably be estimated from a core biopsy specimen; in case of a disparity between the aspirate, the highest value should be used)
• Involved: Uninvolved serum free light chain ratio ≥ 100 (values are based on the serum Freelite assay) The involved free light chain must be ≥ 10 mg/dL >1 focal lesions on MRI studies (each focal lesion must be 5 mm or more in size)
• [C] Calcium elevation in the blood, defined as serum calcium >11 mg/dl or > 1 mg/dL higher than the upper limit of normal
• [R] Renal insufficiency, defined as serum creatinine > 2 mg/dl or creatinine clearance 2 g/dl below the lower limit of normal
• [B] Lytic bone lesions or osteoporosis. one or more osteolytic lesions on skeletal radiography, CT, or PET-CT (if bone marrow has less than 10% clonal plasma cells, more than one bone lesion is required to distinguish from solitary plasmacytoma with minimal marrow involvement)
• Patients must have symptomatic multiple myeloma without advanced organ damage (such as multiple fractures or advanced bone disease causing immobilization, renal failure, spinal cord compression, or organ compromise due to soft tissue plasmacytoma). If immediate therapy with radiation and high-dose steroids (eg, for spinal cord compression) or if triple therapy is clearly advisable from the start, the patient is not eligible for this trial.
• Patients with measurable disease defined as one or more of the following: serum M protein ≥ 1.0 g/dl, urine M-protein ≥ 200 mg/24h, and/or serum FLC assay: involved FLC level ≥ 10 mg/dl with abnormal serum FLC ratio.
• Only non transplant candidates or those who opt to forgo ASCT during first line therapy are eligible
• ECOG performance status ≤ 2
• Female patients must:
• be postmenopausal for at least 1 year before the Screening visit, OR
• be surgically sterile, OR
• If they are of childbearing potential, agree to practice 2 effective methods of contraception, at the same time, from the time of signing the informed consent through 30 days after the last dose of study treatment, OR agree to completely abstain from heterosexual intercourse
• Male patients, even if surgically sterilized (ie, status post-vasectomy), must:
• Agree to practice effective barrier contraception during the entire study treatment period and through 30 days after the last dose of study treatment, OR
• Agree to completely abstain from heterosexual intercourse
• Patients must be able to provide voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.

Exclusion Criteria

• Participant treated with any prior systemic therapy with the exception of the following:
• Treatment by localized radiotherapy for a specific indication within 2 weeks of initiation of treatment.
• Treatment with corticosteroids, not to exceed the equivalent of 160 mg of dexamethasone over a four-week period before initiation of protocol therapy.
• Presence of Primary or associated amyloidosis (AL)
• Participants who plan to proceed with ASCT as part of first line therapy
• Poor tolerability or known allergy to lenalidomide, bortezomib and/or dexamethasone or compounds that have similar chemical or biologic composition to these study d