Phase 3
Completed N=378
Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)
Atrial Fibrillation · Persistent Common Pulmonary Vein
Source: ClinicalTrials.gov NCT01932112 ↗
Enrolled (actual)
378
Serious AEs
0.5%
Results posted
Apr 2016
Primary outcomePrimary: Reconnection of Pulmonary Vein Electrogram After Adenosine Infusion — 92 participants
◆ Published Evidence
Emerging
18citations · ~2 / year
Achievement of successful pulmonary vein isolation: methods of adenosine testing and incremental benefit of exit block.
Summary
The investigators studied the effects of adenosine on the reconnection rate after successful pulmonary veins isolation by radiofrequency catheter ablation in patients with drug-resistant atrial fibrillation
Linked Publications
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Achievement of successful pulmonary vein isolation: methods of adenosine testing and incremental benefit of exit block.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Reconnection of Pulmonary Vein Electrogram After Adenosine Infusion |
92 | — |
| SECONDARY Atrial Fibrillation Recurrence |
— | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosed atrial fibrillation
- recurrence of symptomatic atrial fibrillation in spite of Antiarrhythmic drug use
- written informed consent
Exclusion Criteria
- intracardiac thrombus
- pregnancy
Data sourced from ClinicalTrials.gov (NCT01932112) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.