Phase 4
Completed N=83
IVUS Guidance to Reduce Contrast in Coronary Angioplasty
Contrast Media Reaction · Acute Renal Failure
Source: ClinicalTrials.gov NCT01947335 ↗
Enrolled (actual)
83
Serious AEs
4.8%
Results posted
Jun 2016
Primary outcomePrimary: Total Volume of Iodine Contrast Used During Procedure — 64.5; 20.0 ml
◆ Published Evidence
Highly cited
199citations · ~17 / year
Intravascular ultrasound guidance to minimize the use of iodine contrast in percutaneous coronary intervention: the MOZART (Minimizing cOntrast utiliZation With IVUS Guidance in coRonary angioplasTy) randomized controlled trial.
Summary
This study tests the hypothesis that ultrasound-guided PCI reduces contrast volume during the procedure.
Linked Publications
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Intravascular ultrasound guidance to minimize the use of iodine contrast in percutaneous coronary intervention: the MOZART (Minimizing cOntrast utiliZation With IVUS Guidance in coRonary angioplasTy) randomized controlled trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Volume of Iodine Contrast Used During Procedure |
64.5; 20.0 | — |
| SECONDARY Major Adverse Cardiac Events |
2; 2; 2; 5 | — |
| SECONDARY Incidence of Contrast-induced Nephropathy |
19; 7.3 | — |
Eligibility Criteria
Inclusion Criteria
- Written informed consent
- Age >=18 years
- Coronary artery disease scheduled for percutaneous intervention
- Technical feasibility for intravascular ultrasound to guide coronary angioplasty
- Increased risk for contrast-induced acute renal failure (e.g. age > 80 years, female gender, diabetes, urgent or emergent procedure priority, diabetes, congestive heart failure, increased baseline serum creatinine, decreased calculated or measured creatinine clearance, intra-aortic balloon pumping, previous renal transplantation or single kidney)
Exclusion Criteria
- Anticipated technical impossibility for intravascular ultrasound
- Unknown baseline renal function
- Baseline end-stage renal failure needing dialysis
- Acute renal failure with dynamic change in renal function at the time of index procedure
- Iodine contrast administration <= 72 prior to index procedure
- Known allergy to iodine contrast
Data sourced from ClinicalTrials.gov (NCT01947335) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.