N/A
Completed N=15
Effect of Sildenafil on Diffusion Capacity in Patients With PH and Parenchymal Lung Disease
Source: ClinicalTrials.gov NCT01948518 ↗Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Sep 2014
Primary outcomePrimary: Change in Diffusion Capacity Measured at Baseline and One Hour. — -0.26 ml/min/mmHg — p==0.30
Summary
The purpose of this study was to investigate the acute effects of sildenafil on diffusion capacity, a commonly performed pulmonary function test, which is used to assess the lungs' gas exchange capability.
This study does not assess safety or efficacy of the drug. The study does not have clinical end points. The variables studied are diffusion capacity and 6 minute walk after a single dose of sildenafil.
This study has been completed.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Diffusion Capacity Measured at Baseline and One Hour. |
-0.26 | =0.30 |
| SECONDARY Change in 6 Minute Walk Distance |
1195; 1214 | =0.63 |
Eligibility Criteria
Inclusion Criteria
- Adult patients over age 18 years of age who are able to consent
- Diagnosis of diffuse parenchymal lung disease with concomitant pulmonary hypertension
Exclusion Criteria
- None
Data sourced from ClinicalTrials.gov (NCT01948518). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.