Phase 4
Completed N=70
Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart
Source: ClinicalTrials.gov NCT01961323 ↗Enrolled (actual)
70
Serious AEs
0.0%
Results posted
Nov 2017
Primary outcomePrimary: Improvement in Exercise Tolerance — 9; 8 Participants
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
To investigate whether treatment with Nebivolol in subjects with high blood pressure and abnormal filling of left ventricle (LVDD) improves exercise time by improving Left Ventricular deformation and filling.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Improvement in Exercise Tolerance |
9; 8 | — |
| SECONDARY E Velocity Indexed to e' (E/e' Ratio) of the Left Ventricle |
7.5; 8.8 | — |
| SECONDARY Untwist Rate of the Left Ventricle |
— | — |
Eligibility Criteria
Inclusion Criteria
- History of mild (140-160 / 90-100) to moderate (160-200 / 100-120) hypertension
- LV diastolic dysfunction (>/= Grade1)
- LV ejection fraction >50%
- Indexed left atrial volume >/= 28 mL/m^2
- In sinus rhythm at the time of enrollment
- Willingness to return for the 6-month follow up investigations
Exclusion Criteria
- Presence or history of any of the following at baseline:
- History of mitral valve disease of greater than mild severity or prosthetic mitral valve, congenital heart disease or permanent pacemaker
- Calculated creatinine clearance 180 mm Hg or diastolic BP > 120 mm Hg
- Medical treatment for elevated BP with:
- Calcium channel blocker (e.g. verapamil, nifedipine);
- Alpha blocker (e.g. prazosin);
- Alpha agonist (e.g. α-methyldopa, hydralazine, clonidine)
- Patient unwilling or unable to provide informed consent for study participation
- Pregnancy (current, or anticipated within the study period)
- Secondary Hypertension
- Previous echo contrast allergy
- Poor echocardiography window
- Previous stroke, known carotid stenosis
- Contraindication for beta-blocker therapy (sinus bradycardia twice above normal levels)
Data sourced from ClinicalTrials.gov (NCT01961323). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.