Phase 4
Completed N=80
Fast Track Total Knee Arthroplasty: Local Infiltration Analgesia vs Femoral Nerve Block
Arthroplasty, Replacement, Knee
Source: ClinicalTrials.gov NCT01966263 ↗
Enrolled (actual)
80
Serious AEs
0.0%
Results posted
Jan 2023
Primary outcomePrimary: Stair Climbing Task (SCT) — 14.3; 13.8 seconds
◆ Published Evidence
Established
38citations · ~5 / year
Femoral nerve catheter vs local infiltration for analgesia in fast track total knee arthroplasty: short-term and long-term outcomes.
Summary
The objective of this study is to determine whether either a femoral nerve block (FNB) or local infiltration analgesia (LIA) is a better anesthetic technique to achieve optimal functional outcome after one year in patients receiving a total knee arthroplasty and following a fast track rehabilitation protocol.
Linked Publications
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Femoral nerve catheter vs local infiltration for analgesia in fast track total knee arthroplasty: short-term and long-term outcomes.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Stair Climbing Task (SCT) |
14.3; 13.8 | — |
| SECONDARY Timed Up and Go Test (TUG) |
7.8; 7.6 | — |
| SECONDARY Six Minute Walking Test (6MWT) |
489; 505 | — |
Eligibility Criteria
Inclusion Criteria
- American Society of Anesthesiologists (ASA) physical health status I-II
- patient presents with non-inflammatory primary knee osteoarthritis (radiological confirmation)
- patient is planned for a primary unilateral posterior-stabilized tri-compartmental cemented total knee replacement (Genesis II - PS)
- patient is scheduled for fast track protocol
- patient plans to be available fot follow-up through one year post-operative
- written informed consent
Exclusion Criteria
- any contra-indication for locoregional anesthesia
- any contra-indication for spinal anesthesia
- traumatic osteoarthritis requiring TKA
- an active, local infection or systemic infection
- known hypersensitivity to amide-type local anesthetics
- known intolerance or contraindication for opioids, nonsteroidal antiinflammatory drugs (NSAIDs) or paracetamol
- a Body Mass Index > 40 kg/m2
- inability to walk independently (inability to walk at least 10 consecutive meters without a walking aid)
- scheduled for contralateral TKA within one year postoperative
- scheduled for another operation within 3 months postoperative
- physical, emotional or neurological conditions that would compromize compliance with postoperative rehabilitation and follow-up
- chronic opioid analgesic therapy
- chronic gabapentin or pregabalin analgesic therapy
- rheumatoid arthritis
Data sourced from ClinicalTrials.gov (NCT01966263) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.