N/A
N=79
Study to Assess Perfusion and Patient Satisfaction in Nipple-Areola Mastectomy With Immediate Reconstruction
Ductal Carcinoma in Situ - Category · Breast Cancer · Prophylactic Mastectomy
Bottom Line
View on ClinicalTrials.gov: NCT01969448 ↗Enrolled (actual)
79
Serious AEs
0.0%
Results posted
Apr 2018
Primary outcome: Primary: Percentage of Original Preoperative Blood Supply (Perfusion) Post Nipple Sparing Mastectomy — 63.9; 60.8; 29.9; 40.0 percentage of original preop perfusion
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Inframammary Fold Incision or Lateral Radial Incision (Procedure); Lateral Radial Incision (Procedure); Inframammary Fold Incision (Procedure); Laser-assisted fluorescence angiography (Device); Indocyanine Green (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Washington University School of Medicine
- Primary completion
- Apr 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Original Preoperative Blood Supply (Perfusion) Post Nipple Sparing Mastectomy |
63.9; 60.8; 29.9; 40.0; 54.6; 72.0 | — |
| PRIMARY Percentage of Original Preoperative Blood Supply (Perfusion) Post Reconstruction |
30.6; 35.1; 23.2; 31.3; 21.9; 36.9 | — |
| SECONDARY Breast Q Score |
62.1; 53.8; 69.3; 68.7; 74.1; 68.0 | — |
| SECONDARY Number of Participants With Tissue Expander |
19; 12 | — |
| SECONDARY Mean Operative Times for Mastectomy |
155.3; 177.0 | — |
| SECONDARY Breast Weight |
350; 418 | — |
Summary
The investigators hypothesize that nipple-areola skin sparing mastectomy (NASSM) performed through an inframammary incision has a superior blood supply relative to a lateral oblique incision. Moreover, by minimizing complications and optimizing aesthetic outcomes, the investigators believe it will be associated with significantly higher patient reported outcome scores. The addition of information gained by use of intraoperative laser-assisted fluorescent angiography (measured with the Spy Elite imaging device) will reduce complication rates by directing intraoperative resection of ischemic tissue and limiting the volume of immediate implant placement in instances where real time imaging would suggest compromised perfusion. These quantifiable, objective measures will justify the use of NASSM and immediate implant placement coupled with intraoperative laser-assisted fluorescent angiography in prosthetic based breast reconstruction despite longer operative times.
Eligibility Criteria
Inclusion Criteria
- Patient must be scheduled to undergo either a single or bilateral elective nipple-areola skin sparing mastectomy (NASSM) procedure with planned immediate reconstruction.
- Patient must be 18 years of age or older.
- Karnofsky Performance Scale of at least 80%.
- Patient must be able to understand and willing to sign a written informed consent document.
Exclusion Criteria
- Cognitive impairment.
- BMI 35
- Breast >800 grams or 100 g and <800 g.
- History of radiation to the chest wall or breast being studied
- Patients who have a history of allergy to iodides or iodinated contrast agents
- Surgeon's opinion at the time of surgery that the subject's well-being would be compromised (e.g. significant comorbidities, intraoperative findings of a higher stage cancer or other independent acute health problems). If the contralateral breast is undergoing a nipple-sparing mastectomy with reconstruction as well, then the contralateral breast can be studied so long as there is no compromise to any element of their care.
Data sourced from ClinicalTrials.gov (NCT01969448). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.