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N/A Completed N=32 Randomized Double-blind Basic Science

Multi-ingredient Supplement for Strength and Power

Supplement
Source: ClinicalTrials.gov NCT01971723 ↗
Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Mar 2015
Primary outcomePrimary: Strength Performance Outcomes — 119.48; 120.45; 132.47; 129.37 Kg — p=.38

Summary

It has been suggested that high amounts of total serum testosterone levels correlate with higher lean body mass, lowered fat mass, greater muscle strength, and faster recovery. These suggestions drive athletes and body builders to find ways to raise their testosterone levels. Many athletes and bodybuilders look to alternative methods to anabolic steroids in order increase their testosterone levels without legal repercussions or physiological side effects. Herbs and other plant extracts have been introduced as a possible source to naturally boost testosterone levels. Research supporting the use of herbs and plant extracts has been shown to be equivocal. However, evidence in studies with hypogonadal men suggests that longjack root may naturally boost testosterone levels. Onnit Labs, LLC has packaged this supplement (T+) which claims it can naturally boost testosterone and lower estrogen levels and subsequently improve performance. This product is a powder (11g) that is mixed with 16 oz of water and consumed 20 minutes prior to anaerobic workouts, such as high intensity weight training. T+ is a multi-ingredient supplement that consists of vitamins B5 and B6, magnesium aspartic acid, mucuna pruriens, longjack root, nettle root, red clover luteolin, resveratrol, beta- alanine, branch chain amino acids, L- glutamine, Bioperine, and Fibersol 2. The active ingredients purported to boost plasma testosterone levels are mucuna pruriens, longjack root, and magnesium aspartic acid. The active ingredients claimed to lower plasma estrogen concentrations are red clover, luteolin, resveratrol and nettle root. All other ingredients (Branch Chain Amino Acids and Beta-Alanine) have been documented to improve exercise performance. It is hypothesized that there will not be any physiological changes after supplementation of T+. It is also hypothesized that performance will not be affected by the supplementation of T+.

Outcome Measures

OutcomeResultp-value
PRIMARY
Strength Performance Outcomes
119.48; 120.45; 132.47; 129.37; 102.27; 96.33 .38
PRIMARY
Insulin Outcomes
5.70; 5.83; 5.68; 5.34; 5.52; 6.51 >.05
PRIMARY
Blood Lipid Outcomes
158; 162; 161; 160; 162; 161 >.05
PRIMARY
Total Testosterone Outcomes
564; 473; 525; 415; 548; 475 >.05
PRIMARY
Estrogen Outcomes
32.7; 31.9; 33.2; 35.1; 37.4; 35.5 >.05
PRIMARY
Insulin-like Growth Factor-I Outcomes
166; 213; 157; 207; 163; 237 >.05
PRIMARY
Bio-availableTestosterone Outcomes
321; 282; 286; 234; 313; 273 >.05
PRIMARY
Free Testosterone Outcomes
13.7; 12.0; 12.2; 10.0; 13.4; 11.6 >.05
PRIMARY
Dihydrotestosterone Outcomes
901; 919; 690; 939; 926; 952 >.05
PRIMARY
Cortisol Outcomes
17.0; 20.1; 17.7; 19.9; 19.3; 19.2 >.05
PRIMARY
Sex-hormone Binding Globulin Outcomes
28.2; 23.5; 32.0; 25.5; 30.3; 26 >.05
PRIMARY
Creatine-Kinase Outcomes
2.0; 2.2; 2.5; 1.7; 1.8; 1.8 .05
SECONDARY
Volume Performance Outcomes
32.2; 29.9; 33.1; 31.5; 28; 26 >.05

Eligibility Criteria

Inclusion Criteria

  • Must be familiar with the three main powerlifting movements (squat, bench and deadlift)
  • Must have one month training with a designated strength coach to understand the expectations of the strength coach and movement patterns for performance
  • Have no pre-existing musculoskeletal disorders
  • Participate in the three-week supplement wash out prior to beginning the experiment (except for basic protein supplements and multivitamins)

Exclusion Criteria

  • Female
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01971723). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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