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N/A Completed N=124 Randomized Double-blind Treatment

Behavioral Activation for Smoking Cessation in PTSD

Tobacco Dependence · Post-Traumatic Stress Disorder
Source: ClinicalTrials.gov NCT01995123 ↗
Enrolled (actual)
124
Serious AEs
10.5%
Results posted
Apr 2020
Primary outcomePrimary: Percentage of Participants Who Abstained From Smoking — 23; 21; 20; 19 Participants

Summary

The purpose of this study is to examine whether behavioral activation as an adjuvant to standard smoking cessation treatment improves smoking cessation outcomes among veterans with PTSD relative to a comparably intense combination of standard smoking cessation treatment + health and smoking education. It is expected that behavioral activation will produce more successful results than health and smoking education when paired with standard smoking cessation treatment.

Outcome Measures

OutcomeResultp-value
PRIMARY
Percentage of Participants Who Abstained From Smoking		 23; 21; 20; 19; 22; 14 —
SECONDARY
Time to Smoking Relapse		 88.41; 84.34 —
SECONDARY
Clinician Administered PTSD Scale Score		 30.78; 27.33 —

Eligibility Criteria

Inclusion Criteria

  • Report smoking an average of 10 or more cigarettes daily for at least six months
  • Report a desire to quit smoking
  • Meet criteria for current PTSD
  • Speak and read English
  • Agree to participate in the study
  • Be 18 years old
  • Be a veteran

Exclusion Criteria

  • Meeting criteria for psychotic or bipolar disorder
  • Psychoactive substance abuse or dependence (excluding nicotine dependence) within the past 6 months
  • Inability to give informed, voluntary, written consent to participate
  • Current use of any pharmacotherapy for smoking cessation not provided by the researchers during the quit attempt
  • Use of non-cigarette tobacco products as a primary form of tobacco use
  • Being currently suicidal or homicidal
  • Being medically unable to use the nicotine patch or nicotine gum/lozenge
  • Psychotropic medication changes within 3 months of study initiation and during active treatment
  • Current engagement in evidence-based therapies for PTSD or depression
  • Pregnant or trying to become pregnant
  • Incarceration
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01995123). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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