Phase 2
Completed N=14
The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
Source: ClinicalTrials.gov NCT01996449 ↗Enrolled (actual)
14
Serious AEs
0.0%
Results posted
Feb 2022
Primary outcomePrimary: Muscle Sympathetic Nerve Activity at Rest — 41; 43.8 bursts/minute
Summary
Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex. An increasing body of evidence suggests a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We hypothesize that this effect of aldosterone is mediated by its direct action on the central nervous system and that administration of mineralocorticoid receptor antagonists constitute an effective treatment for EPR overactivity in hypertension, independent of reductions in resting BP.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Muscle Sympathetic Nerve Activity at Rest |
41; 43.8 | — |
| SECONDARY Muscle Sympathetic Nerve Activity During Exercise |
47; 51 | — |
Eligibility Criteria
Inclusion Criteria
- Experiments will be performed on 3 groups of nondiabetic human subjects:
- 1) stage I (140-159/90-99 mmHg) subjects with essential hypertension.
- 2) stage I hypertensive subjects with primary aldosteronism
- 3) normotensive controls.
Exclusion Criteria
- 1) Any evidence of cardiopulmonary disease, left ventricular hypertrophy or systolic dysfunction by echocardiography.
- 2) Blood pressure averaging ≥160/100 mmHg
- 3) Estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m2
- 4) Diabetes mellitus or other systemic illness
- 5) Pregnancy
- 6) Hypersensitivity to nitroprusside, phenylephrine, amlodipine or eplerenone
- 7) Any history of substance abuse or current cigarette use
- 8) Any history of psychiatric illness
- 9) History of malignancy
Data sourced from ClinicalTrials.gov (NCT01996449). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.