Phase 4 N=80 Randomized Single-blind Treatment

Effects of Epidural Local Anesthetics on Propofol Induction

General Anesthesia · Propofol Target-controlled Infusion · Thoracic Epidural Anesthesia

Bottom Line

View on ClinicalTrials.gov: NCT02000973 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2014

Primary outcome: Primary: Propofol Effect-site Concentration — 1.76; 1.14; 1.09; 1.04 ug/ml

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Lidocaine (Drug); Bupivacaine (Drug); Ropivacaine (Drug); Normal Saline (Drug)
Age: Adult, Older Adult · 45+ yrs
Sex: All
Sponsor: First Hospital of China Medical University
Primary completion: Jan 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Propofol Effect-site Concentration	1.76; 1.14; 1.09; 1.04	—
SECONDARY Mean Arterial Pressure	96.40; 99.65; 98.95; 98.25; 99.55; 96.25	—
SECONDARY Heart Rate	71.70; 69.65; 69.00; 74.80; 73.95; 69.15	—
SECONDARY Bispectral Index Score	96.67; 96.70; 97.07; 96.94; 96.20; 90.00	—

Summary

The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.

Eligibility Criteria

Inclusion Criteria

Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.

Exclusion Criteria

liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02000973). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.