Phase 4
Completed N=40
Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Control Study
Source: ClinicalTrials.gov NCT02026141 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Jun 2016
Primary outcomePrimary: Morphine Consumption — 29.2; 61.2 milligrams — p=<0.05
◆ Published Evidence
Established
40citations · ~4 / year
Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial.
Summary
Dexmedetomidine has been often used for procedural sedation. It has also has been shown to have a pain sparing effect. Therefore the investigators propose that if Dexmedetomidine is used for sedation in total knee replacements done under spinal anesthetic, the patients will have less pain up to 24 hours after the procedure.
Linked Publications
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Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Morphine Consumption |
29.2; 61.2 | <0.05 sig |
| SECONDARY Time of First Analgesia Request |
— | — |
Eligibility Criteria
Inclusion Criteria
- Total Knee arthroplasty American Society of Anesthesiologist score of 1-3 Age 18-85 Elective total knee arthroplasty under spinal anesthetic.
Exclusion Criteria
- Contraindication to Dexmedetomidine. (second or third degree heart block, renal or hepatic dysfunction) Contraindication to Spinal Anesthetic Pain being treated by opioids prior to operation Contraindication to premedication Previous total knee arthroplasty
Data sourced from ClinicalTrials.gov (NCT02026141) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.