Phase 2
N=32
Reversal of General Anesthesia With Methylphenidate
Post Operative Cognitive Dysfunction · Emergence From Anesthesia
Bottom Line
View on ClinicalTrials.gov: NCT02051452 ↗Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcome: Primary: Number of Participants With Adverse Events — 0; 0 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Methylphenidate (Drug); Saline (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Massachusetts General Hospital
- Primary completion
- May 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Adverse Events |
0; 0 | — |
| SECONDARY Time to Emergence From General Anesthesia |
7.5; 8.73 | — |
Summary
The aim of this study is to investigate whether methylphenidate (Ritalin) can actively induce emergence from general anesthesia in patients having a pancreaticoduodenectomy (Whipple procedure), a pancreatectomy, or a prostatectomy.
Eligibility Criteria
Inclusion Criteria
- Age 18-75 years
- American Society of Anesthesiologists classification 1 or 2
- Scheduled to undergo a pancreaticoduodenectomy or distal pancreatectomy at Massachusetts General Hospital
Exclusion Criteria
- American Society of Anesthesiologists physical status classification of 3 or beyond.
Data sourced from ClinicalTrials.gov (NCT02051452). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.