N/A
Completed N=50
The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
Cardiac Surgical Procedures
Source: ClinicalTrials.gov NCT02060838 ↗
Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Mar 2017
Primary outcomePrimary: Time to Platelet Aggregation as Measured Using Collagen-epinephrine (EPI) — 260; 261 seconds
Summary
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood is drawn from our patients pre-bypass after obtaining the arterial line and administered back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of heparin with protamine. In our practice we noticed some variability in the impact of ANH on postoperative bleeding; with some patients appearing to show more hemostasis after separation from CPB than others. This is a prospective study to find out if there is an optimal time period that guarantees the largest amount of functioning platelets and what is the best practice for drawing and storing of ANH to guarantee the largest amount of functioning platelets.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time to Platelet Aggregation as Measured Using Collagen-epinephrine (EPI) |
260; 261 | — |
| PRIMARY Time to Platelet Aggregation as Measured Using Collagen-Adenosine (ADP) |
251; 245 | — |
Eligibility Criteria
Inclusion Criteria
- All patients undergoing cardiac surgery on CPB and are determined to be suitable for ANH by the cardiac team during the huddle process per our standard protocol.
Exclusion Criteria
- Patients who are undergoing cardiac surgery on CPB who are determined not to be suitable candidates for ANH by the cardiac team during the huddle process per our standard protocol.
Data sourced from ClinicalTrials.gov (NCT02060838). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.