Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse

Inclusion Criteria

• Male and female subjects
• Age 18 to 50
• Meet current DSM-IV criteria for cocaine dependence who are seeking treatment.

Exclusion Criteria

• Current DSM-IV diagnosis of any psychoactive substance dependence other than cocaine, marijuana, nicotine, or alcohol
• Have a DSM-IV axis I psychiatric disorder or neurological disease or disorder requiring ongoing treatment and/or making study participation unsafe
• Significant current suicidal or homicidal ideation
• Medical conditions contraindicating levodopa/carbidopa or pharmacotherapy (e.g., evidence of any movement disorder, clinically significant pulmonary disease, cardiovascular disease, liver or kidney disease, seizure disorder)
• Taking CNS active concomitant medications
• Taking medications known to have significant drug interactions with the study medication (e.g., CYP P-450-2D6 inhibitors, such as tamoxifen, iron salts, pyridoxine, monoamine oxidase inhibitors, phenothiazines, selegiline, anesthetics)
• Having conditions of probation or parole requiring reports of drug use to officers of the court
• Impending incarceration
• Pregnant or breast feeding for female patients
• Inability to read, write, or speak English
• Having plans to leave the immediate geographical area within 3 months
• Unwillingness or not competent to sign a written informed consent form
• Individuals who have pacemakers, metal or electromechanical implants or metallic foreign bodies
• Patients who are known to be HIV positive will not be included due to possible CNS effects of HIV.
• Alcohol withdrawal symptoms or history of significant previous alcohol withdrawal symptoms