N/A
Completed N=16
Diet Induced Intestinal Mucosal Adaptation
Healthy Conditions
Source: ClinicalTrials.gov NCT02088853 ↗
Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcomePrimary: Mucosal Surface Enlargement — 10.2; 9.9 percentage of muscular mucosae — p=<0.05
Summary
Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mucosal Surface Enlargement |
10.2; 9.9 | <0.05 sig |
| SECONDARY Glucose Induced Electrogenic Responses In-vitro |
42; 2 | <0.05 sig |
| SECONDARY Glycemic Control Following a Test Meal |
699; 732 | 0.05 |
Eligibility Criteria
Inclusion Criteria
healthy volunteer not taking prescribed medications BMI ≤25 kg/m2
Exclusion Criteria
BMI ≥26 kg/m2 smoker previous or current gastrointestinal disease significant abdominal surgery pregnancy/breast feeding drug intolerance of importance (particularly opiates and midazolam used during endoscopy) history of drug addiction
Data sourced from ClinicalTrials.gov (NCT02088853). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.