Phase 2
N=32
Healthy Aging Through Functional Food
Glucose Intolerance · Aortic Stiffness · Vasodilation
Bottom Line
View on ClinicalTrials.gov: NCT02095873 ↗Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Mar 2017
Primary outcome: Primary: Area Under the Curve for Oral Glucose Tolerance Test (oGGT) — 10.8; 11.0; 9.9; 10.6 mM h
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Glyoxalase 1 (Glo1) inducer (Dietary_supplement); Placebo (Dietary_supplement)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Warwick
- Primary completion
- Feb 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Area Under the Curve for Oral Glucose Tolerance Test (oGGT) |
10.8; 11.0; 9.9; 10.6 | — |
| SECONDARY Finger-fold Capillary Density by Capillaroscopy |
115; 119; 125; 128 | — |
| SECONDARY Flow-mediated Dilatation (FMD) |
0.17; 0.18; 0.12; 0.26 | — |
Summary
The purpose of this study is to determine whether dietary inducers of glyoxalase 1 are effective in improving metabolic and vascular health.
Eligibility Criteria
Inclusion Criteria
- BMI 25 - 40 kg/m2 (>23 kg/m2 for Asians), with normal, impaired fasting or impaired postprandial glucose.
- No other relevant morbidities.
- Women will be preferably post-menopausal.
Exclusion Criteria
- Severe hypertriglyceridemia.
- Uncontrolled hypertension, cardiovascular disease, relevant renal or hepatic disease, diabetes, and other relevant morbidity.
- Excess alcohol consumption, smoking, acute pharmacological treatment with drugs affecting glucose metabolism such as steroids and antibiotics.
- Anticoagulants.
- Intake of herbal remedies.
- Food allergies.
Data sourced from ClinicalTrials.gov (NCT02095873). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.