Phase 2
N=100
ACT01 in Combination With Comp01-04 in Patients With Actinic Keratosis
Actinic Keratosis
Bottom Line
View on ClinicalTrials.gov: NCT02126670 ↗Enrolled (actual)
100
Serious AEs
1.0%
Results posted
Feb 2016
Primary outcome: Primary: Treatment Success at End of Study Visit — 66.7; 65.2; 76.0; 66.7 percentage of participants — p=0.799
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- ACT01 (Drug); Comp01 (Drug); Comp02 (Drug); Comp03 (Drug); Comp04 (Drug)
- Age
- Adult, Older Adult · 30+ yrs
- Sex
- All
- Sponsor
- Promius Pharma, LLC
- Primary completion
- Sep 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Treatment Success at End of Study Visit |
66.7; 65.2; 76.0; 66.7 | 0.799 |
| SECONDARY Irritation Score |
56.0; 75.0; 52.0; 66.7 | — |
Summary
The purpose of this study is to determine whether or not ACT01 is effective and tolerable alone or when used in combination with Comp01, Comp02, Comp03 or Comp04 in patients with facial and/or scalp keratosis.
Eligibility Criteria
Inclusion Criteria
- Presence of actinic keratosis lesions on the face and/or scalp within a 25 cm2 contiguous area containing at least four lesions that are non-hypertrophic and non-hyperkeratotic and not larger than 6 mm in longest diameter.
- Age 30-85 years, inclusive.
- Good general health as determined by investigator and supported by medical history and normal or not clinically significant abnormal vital signs (blood pressure and pulse).
Exclusion Criteria
- Severe, uncontrolled auto-immune, cardiovascular, gastrointestinal, hematological, hepatic, neurological, pancreatic, pulmonary or renal disease.
- Dermatologic conditions if present on the face such as acne, atopic dermatitis, seborrheic dermatitis, eczema, rosacea, or albinism.
- Application of 1) chemical peel, 2) dermabrasion, 3) laser abrasion, 4) PUVA (psoralen plus ultraviolet A) therapy, or 5) UVB therapy to the intended treatment area within 180 days prior to the Baseline Visit.
- Use of sun lamps or sun tanning beds or booths during the 14 days prior to the Baseline Visit.
Data sourced from ClinicalTrials.gov (NCT02126670). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.