Mode
Text Size
Log in / Sign up
N/A N=203 Other

Educational Intervention in Pharmacovigilance for Hospital Health Professionals

Adverse Drug Reaction

Enrolled (actual)
203
Serious AEs
Results posted
Aug 2015
Primary outcome: Primary: Absolute Number of ADE Reporting (Change Behavior of Health Professionals) — 215; 3 absolute number of adverse drug events

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Multifaceted educational intervention (Other)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Universidade Estadual Paulista Júlio de Mesquita Filho
Primary completion
Sep 2013

Outcome Measures

OutcomeResultp-value
PRIMARY
Absolute Number of ADE Reporting (Change Behavior of Health Professionals)
215; 3
SECONDARY
Knowledge (Awareness) Regarding Pharmacovigilance
5.2; 2.3 0.00001 sig
SECONDARY
Quality of ADE Reports
5.2; 3.9 <0.0001 sig

Summary

Spontaneous reports by health professionals generate the signals in pharmacovigilance. However, the passive method has limitations and the most important of them are the underreporting and the poor quality of data, hindering the causality assessment of adverse drug events (ADE). Therefore, the present study aimed to validate an educational intervention (EI) in pharmacovigilance for hospital health professionals, in order to analyze the impact on the knowledge, skill and attitude in ADE reporting. Investigators proposed a multifaceted EI which will be developed in four meetings with one hour each. The following activities will be carried out: application of a questionnaire to assess the knowledge, skill and attitude before and after EI; lecture; practical class and education material distribution. The answers of questionnaire are going to be analyzed using content analysis technique. The definitions of World Health Organization and the minimum and desired criteria to fill the ADE form, according to the Pan American Health Organization, are going to be considered gold-standard answers. The statistical test of Wilcoxon-Mann Whitney test for paired samples will be applied, in order to assess the impact of educational intervention on behavior of health professionals (ADE reporting). With the present study, the following hypotheses will be tested: H0= There is no difference between the numbers of ADE reported (behavior/attitudes) before and after the educational intervention. H1= The numbers of ADE reported before and after the educational intervention are different.

Eligibility Criteria

Inclusion Criteria

All health professionals (physicians, pharmacists, nurses, auxiliaries of nurses and pharmacists, as well as the multidisciplinary team - social assistants, physiotherapists, audiologists, nutritionists, psychologists, occupational therapists and administrative officers), with employment link at the hospital under study who agree to participate by signing an informed consent form are going to be enrolled.

Exclusion Criteria

The exclusion criteria meet professionals who will be on sick leave, vacation, those who will not to be registered to carry out the intervention and those who will refuse to answer the questionnaire, despite to having shown interest in participating in the lecture and practical class.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02134587). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

Back to search