N/A
Completed N=197
The WISE (Weightloss Intervention Surgical Effects) Brain Study
Diabetes · Weightloss
Source: ClinicalTrials.gov NCT02137070 ↗
Enrolled (actual)
197
Serious AEs
2.5%
Results posted
Dec 2024
Primary outcomePrimary: Change in BOLD fMRI Signal — 0.10; 0.08; 0.18; -0.01 Connectivity Fisher-z transformation — p=<0.01
Summary
This study is being done to learn about the changes that weight loss causes on brain function, memory and thinking ability in adults. The study does NOT cover any costs associated with bariatric surgery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in BOLD fMRI Signal |
0.10; 0.08; 0.18; -0.01; 0.09; 0.09 | <0.01 sig |
Eligibility Criteria
Inclusion Criteria
- Body Mass Index >35
- Diabetes or no diabetes
- Compatible with MRI Scanning
- Willing to give a small blood sample on 3 occasions
- Capable of providing informed consent
Exclusion Criteria
- Prior neurological disorder
- Mini Mental Status Exam score
- Major psychiatric disturbance (schizophrenia, chronic intractable depression,
- Coronary revascularization, peripheral vascular disease
- Severe cardio vascular disease history
- Unstable medical conditions (cancer)
Data sourced from ClinicalTrials.gov (NCT02137070). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.