N/A
N=31
Neuromodulation of Cognition in Older Adults
Healthy
Bottom Line
View on ClinicalTrials.gov: NCT02137122 ↗Enrolled (actual)
31
Serious AEs
3.2%
Results posted
May 2023
Primary outcome: Primary: Change in NIH Toolbox Fluid Cognition Composite Score — 4.7; 6.1 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sham Stimulation (Device); Transcranial Direct Current Stimulation (Device)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- University of Florida
- Primary completion
- Feb 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in NIH Toolbox Fluid Cognition Composite Score |
4.7; 6.1 | — |
Summary
This study will investigate whether transcranial direct current stimulation enhances the effects of cognitive training in healthy older adults.
Eligibility Criteria
Inclusion Criteria
- Men and women
- Age: 65 to 90 years
- English speaking
- Physically mobile
- working memory function between 0-75th percentile determined by screening results on the POSIT Baseline Cognitive Training computerized tasks.
Exclusion Criteria
- Neurological disorders (e.g., dementia, stroke, seizures, traumatic brain injury).
- Evidence of dementia (NACC UDS scores of 1.5 standard deviations below the mean for age, sex and education adjusted norms in a single cognitive domain on the task).
- Past opportunistic brain infection.
- Major psychiatric illness (schizophrenia, intractable affective disorder, current substance dependence diagnosis or severe major depression and/or suicidality).
- Unstable (e.g., cancer other than basal cell skin) and chronic (e.g, severe diabetes) medical conditions.
- MRI contraindications (e.g., pregnancy, claustrophobia, metal implants that are contraindicated for MRI).
- Physical impairment precluding motor response or lying still for 1 hr and inability to walk two blocks without stopping.
- Certain prescription medications may possibly reduce effects otherwise induced by the tDCS stimulation protocol.
- Hearing or vision deficits that will not allow for standardized cognitive training.
- Left handedness
Data sourced from ClinicalTrials.gov (NCT02137122). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.